MR imaging using nested pulse sequence involving IR pulse

Details MR imaging using nested pulse sequence involving IR pulse MR imaging using nested pulse sequence involving IR pulse

2005-02-01

2005-02-01

Smith, Ruth S. (Department: 3737)

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

C324S307000, C324S309000

Reexamination Certificate

active

06850793

ABSTRACT:
In addition to the known MT (magnetization transfer) effect, an RMT (reverse MT) is newly found, which increases a detected MR signal strength. Both the MT and RMT effects can be explained with mutual interaction, such as phenomena of chemical exchange and/or cross relaxation, acted between a pool of water proton spins and another pool of macromolecule proton spins, for example, within an object. In order to enhance the MT or RMT effect, the frequency bandwidths of RF pulses, such as a 90° RF exciting pulse in a SE or FSE method, an inversion pulse in a FLAIR or fast FLAIR method, and others, are controlled. To enhance the MT effect, the bandwidth is controlled into a wider value (approx. more than 1250 Hz) than the normally (conventionally) used bandwidth, while to obtain the RMT effect, the bandwidth is controlled into a narrower value (approx. less than 1000 Hz) than the normally used bandwidth. Actively controlling the MT or RMT effect permits changed image contrast in MR imaging.

REFERENCES:
patent: 5528144 (1996-06-01), Gullapalli et al.
patent: 6320377 (2001-11-01), Miyazaki et al.

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