MR imaging compositions and methods

Details MR imaging compositions and methods MR imaging compositions and methods

1993-09-14

1998-05-26

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Rare earth containing

424 9323, 424 9361, 424 9364, 424 9365, 534 10, 534 15, 540452, 540465, 546 5, 556 40, 556 50, 556 63, 556116, 556148, A61B 505, A61K 3340, G01N 2400, G01N 3100

Patent

active

057566887

ABSTRACT:
This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.

REFERENCES:
patent: 4916246 (1990-04-01), Felder et al.
patent: 4980148 (1990-12-01), Dean
patent: 4980502 (1990-12-01), Felder et al.
patent: 5130120 (1992-07-01), Weber et al.
patent: 5137711 (1992-08-01), Weber et aal.
patent: 5208324 (1993-05-01), Klaveness et al.
patent: 5358702 (1994-10-01), Unger
patent: 5368840 (1994-11-01), Unger
patent: 5385719 (1995-01-01), Unger et al.
patent: 5407657 (1995-04-01), Unger et al.
patent: 5458127 (1995-10-01), Unger et al.
G.K. Von Schulthess et al., "Polyethylene-glycol-ferrioxamine. A New Magnetic Resonance Contrast Agent", Invest. Radiol., US, 1990, vol. 25, Suppl. 1, p. S48.
Makrlik, Emanuel, "Hydration of Complexes of Some Univalent Cations with Polyethelylene Glycol Ligands in Nitrobenzene Saturated with Water", Collect. Czech. Chem. Commun., vol. 57, pp. 289-295, Feb. 1992.
S. Duewell et al., "Nonionic Polyethylene Glycol-Ferrioxamine as a Renal Magnetic Resonance Contrast agent", Invest Radiol, Jan. 1991, vol. 26, No. 1, pp. 50-57.
HG Botros et al., "Immobilized Metal Ion Affinity Partioning of Cells in Aqueous Two-Phase Systems; Erythrocytes as a Model", Biochim Biophys Acta, 24 May 1991, vol. 1074, No. 1, pp. 79-73.
A. Otto et al., "Recognition and Separation of Isoenzymes by Metal Chelates. Immobilized Metal Ion Affinity Partitioning of Lactate Dehydrogenase Isoenzymes", J. Chromatogr, NL, Jul. 30, 1993, vol. 644, pp. 25-33.
A.A. Bogdanov, Jr., et al., "A New Macromolecule as a Contrast Agent for MR Angiography: Preparation, Properties, and Animal Studies", Radiology, US, Jun. 1993, vol. 187, No. 3, pp. 701-706.
H. Frank et al., "High Resolution 3-D MR Angiography of Pulmonary Vessels in an Animal Model", XVTH Congress of the European Society of Cardiology, Nice, France, Aug. 29-Sep. 2, 1993, p. 188.
V. Molak et al., "Dystrophic Mouse Muscles Have Leaky Cell Membranes", Exp. Neurol, vol. 70, No. 2, pp. 452-457, 1980.
Werner Mueller et al., "Polyethylene Glycol Derivatives of Base and Sequence Specific DNA Ligands: DNA Interaction and Appln for Base Specific Separation of DNA . . .", Nucleic Acids Res, 1981, 9, 95-119.
Shen et al, Journal of Magnetic Resonance Imaging, vol. 2, No. 2, (1992), p. 115.

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