Moving microdroplets

Details Moving microdroplets Moving microdroplets

2005-06-28

2005-06-28

Ludlow, Jan M. (Department: 1743)

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

C422S051000, C422S051000, C422S081000, C422S082000, C422S105000, C436S052000, C436S053000, C436S180000

Reexamination Certificate

active

06911183

ABSTRACT:
The movement and mixing of microdroplets through microchannels is described employing microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

REFERENCES:
patent: 3799742 (1974-03-01), Coleman
patent: 4439526 (1984-03-01), Columbus
patent: 4457329 (1984-07-01), Werley et al.
patent: 4522786 (1985-06-01), Ebersole
patent: 4599315 (1986-07-01), Terasaki et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis et al.
patent: 4919892 (1990-04-01), Plumb et al.
patent: 4963498 (1990-10-01), Hillman et al.
patent: 4967950 (1990-11-01), Legg
patent: 5048554 (1991-09-01), Kremer
patent: 5091328 (1992-02-01), Miller
patent: 5160945 (1992-11-01), Drake
patent: 5192507 (1993-03-01), Taylor et al.
patent: 5223226 (1993-06-01), Wittmer et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5275787 (1994-01-01), Yuguchi et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5364591 (1994-11-01), Green et al.
patent: 5376252 (1994-12-01), Ekstrom et al.
patent: 5416000 (1995-05-01), Allen et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5494639 (1996-02-01), Grzegorzewski
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5533412 (1996-07-01), Jerman et al.
patent: 5585069 (1996-12-01), Zanzucchi et al.
patent: 5587128 (1996-12-01), Wilding et al.
patent: 5637469 (1997-06-01), Wilding et al.
patent: 5651839 (1997-07-01), Rauf
patent: 5660993 (1997-08-01), Cathy et al.
patent: 5700637 (1997-12-01), Southern
patent: 5922591 (1999-07-01), Anderson et al.
patent: 6319469 (2001-11-01), Mian et al.
patent: 6379929 (2002-04-01), Burns et al.
patent: 2672301 (1992-07-01), None
Marmur and Lane,“Strand Separation and Specific Recombination in Deoxyribonucleic Acids: Biological Studies”,Proc.Nat.Acad.Sci., U.S.A.46:453-461 (1960).
Doty et al.,“Strand Separation and Specific Recombination in Deoxyribonucleic Acids:Physical Chemical Studies”,Proc.Nat.Acad.Sci., U.S.A.46:461-477 (1960).
Hayashi et al.,“Restriction of in Vivo Genetic Transcription to one of the Complementary Strands of DNA”,Proc.Nat.Acad.Sci., U.S.A. 50:664-671 (1963).
Smith and Wilcox, “A Restriction Enzyme fromHemophilus influenzae”, J.Mol.Biol.51:379-391 (1970).
Southern, “Detection of Specific Sequences Among DNA Fragments Separated by Gel Electrophoresis”,J.Mol.Biol.98:503-517 (1975).
Maxam and Gilbert, “A new method for sequencing DNA”,Proc. Natl. Acad Sci. USA74:560-564(1977).
Sanger et al., “DNA sequencing with chain-terminating inhibitors”,Proc. Natl. Acad Sci. USA74:5463-5467 (1977).
Sambrook, J. et al., Molecular Cloning, A Laboratory Manual, 2d Ed. Cold Spring Harbor Laboratory Press, New York, 13.7-13.9.
Hunkapiller, M.W., “Advances in DNA sequencing technology”,Curr. Op. Gen. Devl.1:88-92 (1991).
Tabor et al., “DNA sequence analysis with a modified bacteriophage T7 DNA polymerase”,Proc. Natl. Acad. Sci. USA84:4767-4771 (1987).
Innis et al., “DNA sequencing withThermus aquaticusDNA polymerase and direct sequencing of polymerase chain reaction-amplified DNA”,Proc. Natl. Acad. Sci. USA85:9436-9440 (1988).
J. Pfahler et al.,“Liquid Transport in Micron and Submicron Channels”,Sensors and ActuatorsA21-A23: 431-434 (1990).
H.T.G. Van Lintel et al., “A Piezoelectric Micropump Based on Micromachining of Silicon”,Sensors and Actuators15:153-167 (1988).
Smits, “Piezoelectric Micropump with Three Valves Working Peristaltically,”Sensors and ActuatorsA21-A23:203-206 (1990).
Mullis and Faloona, “Specific Synthesis of DNA in Vitro via a Polymerase-Catalyzed Chain Reaction,”Meth. Enzym.155:335-350 (1987).
Arnheim, “Polymerase Chain Reaction Strategy,”Annu. Rev. Biochem.61:131-156 (1992).
Nickerson et al., “Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay,”Proc. Nat. Acad. Sci. USA87:8923-8927 (1990).
Gordon et al., “Capillary Electrophoresis,”Science27:224-228 (1988).
Lawrence Berkeley Lab Presentation, Park City, Utah (1993).
Turner, “New Dimensions in Capillary Electrophoresis Columns,”LC-GCvol. 9 (1991).
Heller and Tullis, “Microelectrophoresis for the separation of DNA fragments,”Electrophoresis13:512-520 (1992).
Manz et al., “Planar chips technology for miniaturization and integration of separation techniques into monitoring systems Capillary electrophoresis on a chip,”J. Chrom.593:253-258 (1992).
Jorgenson and Lukacs, “High-Resolution Separations Based on Electrophoresis and Electroosmosis,”J. Chrom.218:209-216 (1981).
Ansorge et al., “High-throughput automated DNA sequencing facility with fluorescent labels at the European Molecular Biology Laboratory,”Electrophoresis13:616-619 (1992).
Pentoney et al., “A single-fluor approach to DNA sequence determination using high performance capillary electrophoresis,”Electrophoresis13:467-474 (1992).
Tenan et al., “Friction in Capillary Systems,”Journal of Applied Physics53:6687-6692 (1982).
Dussan, “On the Spreading of Liquids on Solid Surfaces Static and Dynamic Contact Lines,”Annual Review of Fluid Mechanics11:371-400 (1979).
Probstein, “Physicochemical Hydrodynamics,”Butterworths Series in Chemical Engineering ed. H. Brenner (1989).
R.F. Service, “The Incredible Shrinking Laboratory,”Science268:26-27 (1995).
Presentation at Cold Spring Harbor (Aug. 31-Sep. 2, 1995).
R. Nowak, “Xeroxing DNA Analysis”.
Manz, A. et al., “Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems”J. Micromech. Microeng.4:257-265 (1994).
Hieptas, P.B. et al., “Ultrathin Slab Gel Separations of DNA Using Single Capillary Sample Introduction System”Anal. Chem.,69:2292-2298 (1997).
Z. Liang et al., “Microfabrication of a Planar Absorbance and Florescence and Fluorescence Cell for Integrated Capillary Electrophoresis Devices,” Anal. Chem. 68:1040-1046 (1996).
Wooley and Mathies, “Ultra-High-Speed DNA Sequencing Using Capillary Electrophoresis Chips,”Anal. Chem.67:3676-3680 (1995).
Effenhauser et al., “Manipulation of Sample Fractions on a Capillary Electrophoresis Chip,”Anal. Chem.67:2284-2287 (1995).
Van der Moolen, J.N. et al., “A Michromachined Injection Device for CZE: Application to Correlation CZE”Anal. Chem.,69:4220-4225 (1997).
Chiu et al. “Injection of Ultrasmall Samples and Single Molecules into Tapered Capillaries”Anal. Chem.69:1801-1807 (1997).

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