Surgery – Miscellaneous
Patent
1998-09-18
2000-05-16
Winakur, Eric F.
Surgery
Miscellaneous
119421, 604151, 604247, A61B 1900, A01K 103
Patent
active
060622245
ABSTRACT:
A movement-responsive system for conducting tests on freely-moving animals is disclosed. The invention includes a container for housing the animal, a mechanism for rotating the container in response to rotational movement of the animal, and one or more test leads connected to the animal for performance of biomedical tests such as infusion, in vivo ultrafiltration, laser-doppler monitoring of blood flow, electrical stimulation and in vivo microdialysis, and a method for automated micro sampling of body fluids in free-moving animals. Because the cage is rotated in response to the animal's rotational movement, no swivel connectors are needed. A rotational sensor assembly is provided to detect rotational movement of the animal within the container. A vertical sensor assembly is mounted to the counterbalanced arm for monitoring vertical movements of the animal. The outputs of the sensor assemblies are routed to a computer or other device for monitoring and/or analyzing the activity of the animal. The container is configured to act as an operant chamber or a metabolic chamber by locating a hole in the bottom of the container and through the rotating mechanism. The invention also enables a new method for sampling body fluids of the animal without restricting the animal's movements. The sampling method uses a syringe pump to result in high fidelity fluid control greatly increasing repeatability of experiments. Further, the method employs pinch valves to control fluid flow in conjunction with an anticoagulant coated tubing, thereby resulting in a blood sampling method that does not require the use of heparinized sterile saline solution as a wash fluid.
REFERENCES:
patent: 3897751 (1975-08-01), Gullino et al.
patent: 3999519 (1976-12-01), Rodemeyer
patent: 4284034 (1981-08-01), Belew
patent: 5345943 (1994-09-01), Hargreaves et al.
patent: 5419312 (1995-05-01), Arenberg et al.
patent: 5558073 (1996-09-01), Pomeranz et al.
patent: 5564434 (1996-10-01), Halperin et al.
patent: 5598847 (1997-02-01), Renger
patent: 5816256 (1998-10-01), Kissinger et al.
M.A. Parada, et al., Journal of Neuroscience Methods 60, Jan. 12, 1995, 133-139.
H. Matsumura, et al., Journal of Neuroscience Methods 57, Jun. 24, 1994, 145-149.
B. Greenstein, ed., Neuroscience Research Methods, Clark et al., vol. 1, Chapter 10, pp. 205-222.
H2 Harvard Single-Station Operant Behavioral Lab Packages, Harvard Apparatus, Natick, MA., Brochure.
G2 Metabolic Cages for Rodents, Harvard Apparatus, Natick, MA., Brochure.
Complete Metabolic Chamber System, Kent Scientific Corporation, Litchfield, CT., Brochure.
H14 Activity Meters and Monitoring Systems, Harvard Apparatus, Natick, MA., Brochure.
Bohs Curtis E.
Evans Donnie A.
Gunaratna W. Gamini
Hampsch James M.
Kissinger Candice B.
Bioanalytical Systems, Inc.
Gridley Doreen J.
Swift Michael A.
Winakur Eric F.
LandOfFree
Movement-response system for conducting tests on freely-moving a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Movement-response system for conducting tests on freely-moving a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Movement-response system for conducting tests on freely-moving a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-250437