Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1993-04-21
1994-07-12
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
A61K 716
Patent
active
053286820
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to oral hygiene compositions, and in particular to mouthwash compositions.
Oral hygiene compositions fall into two main categories: dentifrices and mouthwashes. Dentifrices generally contain an insoluble dentally acceptable abrasive which is utilised to physically cleanse the surface of the teeth. Dentifrices are generally provided in the form of solid or pasty preparations which can be readily applied to a toothbrush, for example, powders, pastes or viscous gels.
Mouthwash compositions known hitherto generally comprise solutions containing small amounts of colourings, flavourings and antibacterial or other active ingredients. These solutions have found use as breath-freshening, antiseptic and/or anti-plaque mouthrinses or gargle preparations and are commonly used in addition to conventional tooth cleansing dentifrices.
Whilst mouthwashes and abrasive dentifrices have been produced as separate products for many years, it has not hitherto been suggested that a satisfactory form of combined product could be prepared in which an effective amount of abrasive could be maintained in an organoleptically acceptable stable suspension having a sufficiently low viscosity to be used as a mouthwash preparation.
The present invention provides an abrasive mouthwash composition which comprises having a viscosity (Brookfield) in the range of 1 to 2000 cps.
Surprisingly, the invention provides mouthwash compositions containing an effective amount of abrasive maintained in a substantially stable suspension having a sufficiently low viscosity to be used as a mouth rinsing preparation. Preferably the pourable suspensions have a viscosity in the range of 1 to 2000 cps, more preferably 20 to 1500 cps, particularly 100 to 1000 cps e.g. 200 to 600 cps (measured on a Brookfield LVT viscometer at speed 12 with spindle LV3). The mouthwash compositions according to the invention have a mildly abrasive action on the teeth when rinsed around in the mouth and as such can be utilised by the consumer as an "easy-to-use" convenience product to replace conventional mouthwashes and dentifrices. Preferably, the novel mouthwashes are used, in conjunction with a toothbrush, to thoroughly cleanse the teeth by the combined action of abrasive and toothbrush, thereby providing a combined "rinse and rush" product. If desired, the abrasive mouthwashes may also be used in a conventional manner as pre- or post-brushing rinses which have excellent teeth cleansing and mouth freshening properties.
In the preferred practice of the invention, an abrasive mouthwash as herein described is used regularly, preferably 1 to 3 times daily, in place of a conventional dentifrice. A typical usage involves rinsing the mouth with, for example, 5 to 10 ml of the composition, expelling the bulk of the composition from the mouth, brushing the teeth with a toothbrush and finally re-rinsing the oral cavity with a further 5 to 10 ml of either mouthwash or water. It has been found that sufficient composition remains in the mouth after expulsion to give a satisfactory foaming and abrasive action, when used in conjunction with a toothbrush, and to provide a long-lasting fresh mouthfeel after use.
Typical dentally acceptable abrasives include insoluble calcium salts such as calcium carbonate, available commercially for example under the trade name Sturcal (Sturge), and various calcium phosphates, alumina, silica, synthetic resins and mixtures thereof. Suitable dentally acceptable abrasives may generally be defined as those having a radioactive dentine abrasion value (RDA) of from about 30 to about 200 at the concentrations used in the compositions of the present invention. Preferred abrasives are non-crystalline silica abrasives, particularly in the form of precipitated silica or milled silica gels available commercially for example under the trade names Zeodent (Zeofinn OY) and Syloblanc (Grace) respectively. Preferred compositions according to the invention comprise 1 to 20%, more preferably 4% to 15% by weight of silica abrasive.
The mouthwashes a
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WPI File Supplier, Derwent Publications Ltd, AN-80-57547, & JP, A, 55085513, 28 Jun. 1980.
Phillips Kathryn A.
Pullen John H.
Singh Rabinder
Boots Company plc
Rose Shep K.
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