Mouse λ light chain locus

Details Mouse λ light chain locus Mouse λ light chain locus

2002-06-21

2009-06-02

Wehbe, Anne Marie S (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Method of making a transgenic nonhuman animal

Involving breeding to produce a double transgenic nonhuman...

C800S021000

Reexamination Certificate

active

07541513

ABSTRACT:
The present invention provides in a first aspect a mouse in which the λ(lambda) light chain locus has been functionally silenced. In one embodiment, the mouse λ light chain locus was functional silenced by deletion of gene segments coding for the λ light chain locus. In a further aspect, a mouse containing functionally silenced λ and κ (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.

REFERENCES:
patent: WO94/02602 (1994-02-01), None
patent: WO96/33735 (1996-10-01), None
patent: WO98/24884 (1998-06-01), None
patent: WO00/26373 (2000-05-01), None
Houdebine et al. (2000) Transgenic Research 9:305-320.
Kolb et al. (1999) Gene 227:21-31.
Sigmund, C., (2000) Arterioscler. Thromb. Vasc. Biol., p. 1425-1429.
Leiter et al. (2002) Diabetologia 45:296-308.
Lariviere et al. (2001) J. Pharm. And Exp. Therap. 297:467-473.
Zou et al. (2005) J. Immunology 175:3769-3779.
Bell et al., The EMBO Journal 13(4): 816-826 (1994).
Boudinot et al., European Journal of Immunology 24(9): 2013-2017 (1994) (Abstract XP-002238056).
Brüggemann et al., Proc. Natl. Acad. Sci. USA 86: 6709-6713 (1989).
Donohoe et al., The Journal of Immunology 164: 5269-5276 (2000).
Gu et al., Cell 73: 1155-1164 (1993).
Hamers-Casterman et al., Nature 363(6428): 446-448 (1993) (Abstract XP-002238053).
Hogan et al., In: Manipulating the Mouse Embryo, Section E, a laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp. 217-251 (1994).
Hogan et al., In: Manipulating the Mouse Embryo, Section F, a laboratory manual, Cold Spring Harbor Laboraty Press, Cold Spring Harbor, pp. 253-289 (1994).
Li et al., Proc. Natl. Acad. Sci. 93: 6158-6162 (1996).
March et al., Analytical Biochemistry 60: 149-152 (1974).
Miller et al., Nature 295: 428-430 (1982).
Nicholson et al., The Journal of Immunology 163: 6898-6906 (1999).
Popov et al., J. Exp. Med. 189(10): 1611-1619 (1999).
Riechmann et al., Journal of Immunological Methods 231(1-2): 25-38 (1999) (Abstract XP-002238054).
Selfridge et al., Somatic Cell and Molecular Genetics 18(4): 325-336 (1992).
Transue et al., Proteins 32(4): 515-522 (1998) (Abstract XP-002238055).
Zou et al., Eur. J. Immunol. 25: 2154-2162 (1995).
Li et al., Proc. Natl. Acad. Sci. USA 93: 6158-6162 (1996).
Lonberg, Nature Biotechnology 23(9): 1117-1125 (2005).
Madsen et al., Proc. Natl. Acad. Sci. USA 96: 10338-10343 (1999).
Schlake et al., Oncogene 18: 6078-6082 (1999).
van Deursen et al., Proc. Natl. Acad. Sci. USA 92: 7376-7380 (1995).
Zheng et al., Molecular and Cellular Biology 20(2): 648-655 (2000).
Zou et al., The Journal of Immunology 170: 1354-1361 (2003).
Hunt et al., Journal of Immunological Methods 65: 199-205 (1983).
Thompson et al., Journal of Neuroimmunology 2: 321-330 (1982).

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