Mouse spermatogenesis genes related to human male sterility

Details Mouse spermatogenesis genes related to human male sterility Mouse spermatogenesis genes related to human male sterility

2003-02-14

2010-11-30

Lundgren, Jeffrey S. (Department: 1639)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C506S007000, C530S387300

Reexamination Certificate

active

07842783

ABSTRACT:
The present invention provides a polynucleotide or a complementary sequence thereof, which polynucleotide is complementary to mRNA transcribed from a human male infertility-associated gene Scot-t, and has one or more mutations selected from the following group: “t” at 870th position is replaced by “g”; and “t” at 1667th position is replaced by “c”, in the DNA sequence of SEQ ID NO:168; various molecular biological materials relating thereto; various molecular biological materials relating to male infertility-associated gene mutations; and various test methods and diagnostic methods using the same.

REFERENCES:
patent: 6090555 (2000-07-01), Fiekowsky et al.
Tschanter et al., Human Reproduction 19(12):2771-2776 (2004).
Burton et al., Mol. Endocrinol., 20(10): 2504-2513 (2006).
Bannister et al., PLOS Biology, 5(5):e105 1016-1025 (2007).
Magyari et al., World J. Gastroenterol. 13(15):2205-2208 (2007).
Bagieyeva et al., Molecular Vision, 13:1458-1468 (2007).
Goodman, Seminars in Hematology, 45(3):135-140 (2008).
Tanaka et al., Journal Human Reproduction, 8(1):16-23 (2001).
S. Vijayaraghavan et al., “Isolation and Molecular Characterization of AKAP110, A Novel, Sperm-Specific Protein Kinase A-Anchoring Protein”, Mol. Endocrinol., 1999, vol. 13, No. 5, pp. 705-717.

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