Mouse monoclonal antibodies to Hepatitis E virus and methods for

Details Mouse monoclonal antibodies to Hepatitis E virus and methods for Mouse monoclonal antibodies to Hepatitis E virus and methods for

1996-08-22

1997-09-16

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435339, 5303883, 436820, C12Q 170, G01N 33576, C07K 1608, C12N 518

Patent

active

056679661

ABSTRACT:
Monoclonal antibodies are described which specifically bind to Hepatitis E Virus (HEV), and more particularly to HEV orf-3 antigen. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

REFERENCES:
Antibodies, A Laboratory Manual, Ed Harlow, Cold Spring Harbor Laboratory and David Lane, Imperial Cancer Research Fund Laboratories. Cold Spring Harbor Laboratory 1988, pp. 567-569.
"Epitope Mapping in Proteins of Hepatitis E Virus", Y. E. Khudyakov, et al., Virology, vol.: 194, No. 1, pp. 89-96 (May 1993).
"Hepatitis E Virus (HEV): Molecular Cloning and Sequencing of the Full-Length Viral Genome", A.W. Tam, et al., Virology, vol.: 185, No. 1, pp. 120-131, (1991) New York, NY, USA.
"Human Linear B-cell Epitopes Encoded by the Hepatitis E Virus Include Determinants in the RNA-Dependent RNA Polymerase", M. Kaur, et al., Proceeding of the National Academy of Sciences of the USA, vol.: 89, No. 9, 1 May1992 Washington, D.C.
Sevier et al., Monoclonal Antibodies in Clinical Immunology, Clin. Chem. 27(11):1797-1806, 1981.
Kaur et al., Human linear B-cell epitopes encoded by the hepatitis E virus include determinants in the RNA-dependent RNA polymerase, Proc. Natl. Acad. Sci. 89:3855-3858, 1992.
Yarbough et al., Hepatitis E Virus Identification of Type-Common Epitopes, J. Virol. 65(11):5790-5797, 1991.

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