Mouse model with human immune system

Details Mouse model with human immune system Mouse model with human immune system

1995-08-04

2000-05-09

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800 11, 424 91, 424 92, 424 931, 424534, 424529, C12N 1500, A61K 3500

Patent

active

060606436

ABSTRACT:
The present invention provides a non-human genetically immunodeficient mammal the peripheral blood of which contains a non-lethal percent of T-cells of human origin which is at least 20% as well as a non-human genetically immunodeficient mammal having a lethal percent of T-cells of human origin in the peripheral blood which is at least 60%. Also provided is a method of screening a substance for anti-HIV activity comprising obtaining a non-human genetically immunodeficient mammal having a lethal percent of human T-cells in the peripheral blood which is at least 60%; infecting the mammal with an amount of HIV sufficient to rescue the mammal from death from the effects of the lethal percent of human T-cells; administering the substance to the mammal; and determining if the substance kills the mammal by inhibiting the rescue of the mammal by HIV, the death of the mammal indicating a substance having anti-HIV activity.

REFERENCES:
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