Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Patent
1996-04-05
1999-08-31
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
435375, 435377, 424 937, 424 921, C12N 500, C12N 1500, A01N 6300, A61K 4900
Patent
active
059455764
ABSTRACT:
Methods and compositions for preparing a mouse model of an inflammatory skin condition are disclosed. The methods involve administering donor lymphocytes to a recipient immune deficient mouse to induce the inflammatory skin response. The mouse models are useful for testing the efficacy of a therapeutic agent for treating the inflammatory skin condition. In particular, the mouse models are useful for screening therapeutic agents for treating human psoriasis.
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Parker Christina M.
Schon Michael P.
Brigham & Women's Hospital Inc.
Crouch Deborah
Martin Jill D.
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