Mouse model for Type II diabetes

Details Mouse model for Type II diabetes Mouse model for Type II diabetes

2007-04-10

2007-04-10

Wehbe′, Anne M. (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

The nonhuman animal is a model for human disease

C800S018000, C800S021000

Reexamination Certificate

active

11041013

ABSTRACT:
The present invention relates to a Type II diabetes model mouse, having a causative gene responsible for the following characteristics (1) to (3) in the heterologous or homologous state, wherein the characteristics are autosomal recessive genetic traits: (1) having a higher blood sugar level as compared to a normal strain mouse at 10 to 14 weeks of age and having a blood glycosylated hemoglobin concentration of 2.5% or higher at 10 to 14 weeks of age or older; (2) being positive in test for urine sugar at 10 to 14 weeks of age; and (3) exhibiting essentially no inflammation of the pancreatic islets and having a blood insulin concentration equivalent to or higher than that of a normal strain mouse. According to the present invention, there is provided a novel mouse having a gene responsible for the spontaneous development of type II diabetes.

REFERENCES:
patent: 20040651581 (2004-03-01), None
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Ueda et al., “The NSY Mouse: A New Animal Model of Spontaneous NIDDM with Moderate Obesity”, Diabetologia, 1995, pp. 503-508, vol. 38.
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