Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1993-11-03
1997-04-29
Stone, Jacqueline M.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
435354, 435325, C12N 500, C12N 1500
Patent
active
056251220
ABSTRACT:
A mutant non-human mammal lacking expression of the lymphocyte-specific tyrosine kinase p56.sup.lck. Lck deficient mice possess few peripheral T lymphocytes and a pronounced thymic atrophy. The remaining thymus contains immature thymocytes surrounded by a perturbed thymic microenvironment. p56.sup.lck appears to play a crucial role in early thymocyte differentiation.
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Crouch Deborah
Stone Jacqueline M.
The Ontario Cancer Institute
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