Mouse having a disrupted CD4 gene

Details Mouse having a disrupted CD4 gene Mouse having a disrupted CD4 gene

1995-03-06

1997-12-16

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4352401, C12N 500

Patent

active

056987650

ABSTRACT:
A mutant mouse strain without CD4 expression has been generated by disrupting the CD4 gene using embryonic stem cell technology. In these mice CD4.sup.+ T lymphocytes are not present in peripheral lymphoid organs, but the development of CD8.sup.+ T cells and myeloid components is unaltered, indicating that expression of CD4.sup.+ on progenitor cells and CD4.sup.+ CD8.sup.+ (double positive) thymocytes is not obligatory. These mice have markedly decreased helper cell activity for antibody responses, whereas cytotoxic T cell activity against viruses was within normal range of that generated by CD4.sup.+ mice. This differential requirement for CD4.sup.+ helper T cells has important implications for the understanding of the immune function in a variety of immune disorders, including AIDS, in which the CD4.sup.+ cells are reduced or absent.

REFERENCES:
Zijlstra et al (1989) Nature 342, 435-438.
Gorman et al (1987) Proced. Natl. Acad. Sci. 84, 7644-7648.

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