Mouse exhibiting characteristics of Rothmund-Thomson...

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

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C800S022000

Reexamination Certificate

active

07541511

ABSTRACT:
A non-human mammal, especially a mouse exhibiting a characteristic of Rothmund-Thomson syndrome prepared by introducing a mutation into exon 13 of RECQL4 gene; and method of preparation thereof are provided.

REFERENCES:
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Wall, R.J. 1996. Theriogenology 45:57-68.
Mullins et al. (1996, Clin. Invest. vol. 97, No. 7, 1557-1560).
Campbell and Wilmut (Theriogenology, 1997. vol. 47, No. 1, pp. 63-72).
Bradley et al. 1992. Biotechnology, vol. 10, pp. 534-539.
Ohhata et al.; “Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicaseRECQL5β,” Elsevier Science B.V., Gene 280, 2001, pp. 59-66.
Kitao et al., “Mutations inRECQLAcause a subset of cases of Rothmund-Thomson syndrome,”Nature Genetics, vol. 22, May 1999, pp. 82-84.
Kitao et al.; “Rothmund-Thomson Syndrome Responsible Gene,RECQLA: Genomic Structure and Products,”Genomics, vol. 61, 1999, pp. 268-276.
Hoki et al.: “Growth retardation and skin abnormalities of the Recq14-deficient mouse,” 2003, vol. 12(18), pp. 2293-2299.

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