Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-01-17
2006-01-17
Tate, Christopher R (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200
Reexamination Certificate
active
06987089
ABSTRACT:
The present invention relates to novel mouse CIA protein and CIA gene having anti-apoptotic activity isolated by yeast 2-hybrid screening which inhibit apoptosis mediated by caspase activated-DNase, CAD and apoptosis signal-regulating kinase 1, ASK1. Since mouse CIA protein and CIA gene of the present invention inhibit apoptotic cell death and DNA fragmentation by selectively interacting with CAD and ASK1 as a negative regulator, CIA protein is useful for an effective inhibitor of CAD and ASK1 protein or a cure of various diseases related to cell death such as disease of degenerative cranial nerve system, apoplexy, cancer, immune disorders or inflammation, and CIA gene is effective for a gene theraphy of the same diseases.
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Chi Sung Wook
Cho Ssang-Gu
Choi Eui-Ju
Kim Jin Woo
Lee Yong Hee
Choi Eui-Ju
Cordero Garcia Marcela M
Gates & Cooper LLP
Tate Christopher R
LandOfFree
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