Mouse cardiac conduction system model

Details Mouse cardiac conduction system model Mouse cardiac conduction system model

2008-07-15

2008-07-15

Paras, Jr., Peter (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S013000, C800S014000

Reexamination Certificate

active

07399902

ABSTRACT:
The present invention relates to a transgenic mouse which has integrated a reporter gene in the locus of the Cx40 gene, wherein said reporter gene is expressed in the different components of the cardiac conduction system (CCS) including the atrio-ventricular node (AVN). His bundle, bundle branches and Purkinje fibers.

REFERENCES:
Anumonwo, Justus M.B., et al., “Action Potential Characteristics and Arrhythmogenic Properties of the Cardiac Conduction System of the Murine Heart”, Circulation Research, Aug. 17, 2001, pp. 329-335, 2001 American Heart Association Inc., USA.
Gourdie, Robert G., et al., “Development of Cardiac Pacemaking and Conduction System Lineages”, Molecular Basis of Cardiovascular Disease, 2nd Edition, (ed. KR Chien), pp. 1-47, USA.
Jay, Patrick Y., et al., “Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system”, The Journal of Clinical Investigation, vol. 113, No. 8, Apr. 2004, pp. 1130-1137, Ann Arbor, Michigan, USA, doi:10.1172/JCI200419846.
Meysen, Sonia, et al., “Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system”, Development Biology (2007), doi:1016/j.ydbio.2006.12.044.
Miquerol, Lucile et al., “Architectural and functional asymmetry of the His-Purkinje system of the murine heart”, Cardiovascular Research 63 (2004), pp. 77-86, 2004 European Society of Cardiology, Elsevier B.V., Netherlands, doi:10.1016/j.cardiores.2004.03.007.
Myers, Dina C., et al., “Toward an Understanding of the Genetics of Murine Cardiac Pacemaking and Conduction System Development”, The Anatomical Record Part A, 280A:1018-1021 (2004), 2004 Wiley-Liss Inc., Wilmington, Delaware, USA, doi:10.1002/ar.a.20077.
Nguyen-Tran, Van T.B., et al., “A Novel Genetic Pathway for Sudden Cardiac Death via Defects in the Transition between Ventricular and Conduction System Cell Lineages”, Cell, vol. 102, pp. 671-682, Sep. 1, 2000, 2000 Cell Press, Cambridge, MA, USA.
Pashmforoush, Mohammad, et al., “Nkx2-5 Pathways and Congenital Heart Disease: Loss of Complete Heart Block”, Cell, vol. 117, 373-386, Apr. 30, 2004, 2004 Cell Press, Cambridge, MA, USA.

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