Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-03-14
2010-06-01
Blanchard, David J (Department: 1611)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S741000
Reexamination Certificate
active
07728041
ABSTRACT:
Disclosed herein are motuporamine mimic agents and methods of making and using same. Particularly exemplified are motuporamine mimic agents comprising cytotoxic activity and/or anti-metaplastic activity.
REFERENCES:
Wang et al., Molecular Requirements for Targeting the Polyamine Transport System. J. Med. Chem., 2003, 46, 2672-2682.
Wang et. al., Synthesis and Biological Evaluation of N1-(Anthracen-9-ylmethyl)triamines as Molecular Recognition Elements for the Polyamine Transporter, J. Med. Chem., 46 (13), 2663-2671, 2003.
Breitbeil et al, “Modeling the Preferred Shapes of Polymaine Transpoter Ligands and Dihydromotuporamine-C Mimics: Shovel versus Hoe”, J. Med. Chem. 49, pp. 2407-2416 (2006).
Beusse Wolter Sanks Mora & Maire
Blanchard David J
Frazier Barbara
University of Central Florida Research Foundation Inc.
Van Dyke Timothy H.
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