Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-07-24
2007-07-24
Rawlings, Stephen L. (Department: 1643)
Chemistry: molecular biology and microbiology
Vector, per se
C435S325000, C536S023500, C530S350000
Reexamination Certificate
active
10723148
ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of HsKip3, antibodies to HsKip3, methods of screening for HsKip3a modulators using biologically active HsKip3, and kits for screening for HsKip3a modulators.
REFERENCES:
patent: 6436686 (2002-08-01), Beraud et al.
patent: 6455293 (2002-09-01), Beraud et al.
patent: 6492158 (2002-12-01), Beraud et al.
patent: 6534309 (2003-03-01), Beraud et al.
patent: 6562610 (2003-05-01), Beraud et al.
patent: 6680369 (2004-01-01), Beraud et al.
patent: WO 01/96593 (2001-12-01), None
patent: WO 01/96593 (2001-12-01), None
Ahn et al., “The Structural and functional diversity of dystrophin,”Nature Genetics, 3:283-291 (1993).
Burgess et al., “Possible Dissociation of the Heparin-binding and Mitogenic Activities of Heparin0binding (Acidic Fibroblast) Growth Factor-1 from Its Receptor-binding Activities by Site-directed Mutagenesis of a Single Lysine Residue,”J. Cell Biol., 111:2129-2138 (1990).
Bork, P., “Powers and pitfalls in sequence analysis: the 70% hurdle,”Genome Research, 10:398-400 (2000).
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,”Science, 247:1306-1310 (1990).
Cawthon et al., “cDNA Sequence and Genomic Structure ofEV12B, a Gene Lying within an Intron of the Neurofibromatosis Type 1 Gene,”Genomics, 9:446-460 (1991).
Debernardi et al., “Identification of a Novel Human Kinesin-Related Gene (HK2) by the cDNA Differential Display Technique,”Genomics, 42:67-73 (1997).
De Plaen et al., “Structure, chromosomal localization, and expression of 12 genes of the MAGE family,”Immunogenetics, 40:360-369 (1994).
Efferth et al., “Involvement of the kinesin heavy chain in the sequence dependent synergism of taxol and cisplatin,”Proceedings of the American Association for Cancer Research, 37:378, abstract # 2579 (1996).
Gura, T., “Systems for Identifying New Drugs Are Often Faulty,”Science, 278:1041-1042 (1997).
Harris et al., “Polycystic Kidney Disease 1: Identification and Analysis of the Primary Defect,”J. of American Society of Nephrology, 6:1125-1133 (1995).
Hirokawa et al., “Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport,”Science, 279:519-526 (1998).
Lazar et al., “Transforming Growth Factor α: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities,”Mol. and Cellular Biol., 8(3):1247-1252 (1988).
Nagai et al., “Identification of the full-lengthKIAA0591gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2,”Int. J. Oncology, 16:907-916 (2000).
Pereira et al., “Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila,”J. Cell Biol., 136:1081-1090 (2000).
Purnelle et al., Genbank Accession #AL023587. Direct Submission, S. pombe chromosome II cosmid c649 (1988).
Reiger et al.,Glossary of Genetics and Cytogenetics: Classical and Molecular, 4th edition, Springer-Verlag, Berlin, pp. 17-18 (1976).
Reiger et al., Genbank Accession #Z72739; Y3135. Direct Submission, S. cerevisiae chromosome VII (1996).
Sakowicz et al., “A Marine Natural Product Inhibitor of Kinesin Motors,”Science, 280:292-295 (1998).
Sippel et al., “Site-directed Mutagenesis within an Ectoplasmic ATPase Consensus Sequence Abrogates the Cell Aggregating Properties of the Rat Liver Canalicular Bile Acid Transporter/Ecto-ATPase/Cell CAM 105 and Carcinoembryonic Antigen*-,”J. Biol. Chem., 27(51):33095-33104 (1996).
Stewart et al., Genbank Accession #U89264. Direct submission, Dm Kinesin-like protein 67a (1997).
Sugano et al., GenBank Accession #AW154058, “cloned polynucleotide sequence encodes a kinesin that has an amino acid sequence that is 100% identical to SEQ ID BO: 2,” (1999).
Tucker et al., “Probing the Kinesin-Microtubule Interaction*,”J. Biol. Chem., 272(14):9481-9488 (1997).
Woehlke et al., “Microtubule Interaction Site of the Kinesin Motor,”Cell, 90:207-216 (1997).
Wood et al., Genbank Acession #Z97211. Direct Submission. S. pombe chromosome II cosmid c2F12 (1997).
Genbank Accession #BG420786, NIH-MGC http://mgc.nci.hih.gov/. polynucleotide sequence comprises a sequence that is greater than 60% identical to SEQ ID NO: 1 (1999).
Skolnick, J. et al., “From genes to protein structure and function: novel applications of computational approaches in the genomic era”Trends Biotechnol.(Jan. 2000) 18(1):34-39.
Beraud Christophe
Craven Andrew
Davies Katherine A.
Patel Umesh A.
Sakowicz Roman
Cytokinetics Inc.
Rawlings Stephen L.
Townsend and Townsend / and Crew LLP
LandOfFree
Motor proteins and methods for their use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Motor proteins and methods for their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Motor proteins and methods for their use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3762806