Motilin-like polypeptide and use thereof

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 698, 4353201, 530324, 536 2351, C07K 1463, C12N 1516, C12N 1563, C12N 1567

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054590493

ABSTRACT:
A process for the preparation of a polypeptide of the formula ##STR1## wherein A' is Pro, Gly, Asp or Ser; B' is Gly, Asn or Ser; C is Gln, Glu or Asp; D is Asn, Glu or Asp; X' is a residue of amino acid other than Met; E is Gln, Lys or Arg, and Y' is a residue of homoserine or homoserine-lactone, as well as a recombinant DNA and expression plasmid for preparing the polypeptide.

REFERENCES:
Brown et al., Gastroenterology, 62, pp. 401-404 (1972).
Schubert et al., Can. J. Biochem., 52, pp. 7-10 (1974).
Christofides et al., Gastroenterology, 80, pp. 456-460 (1981).
Strunz et al., Scand. J. Gastroenterology, 11, pp. 199-203 (1976).
Seino et al., FEBS Letters, 223, pp. 74-76 (1987).
Sung, W. L. et al. PNAS 83:561-565 (1986).

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