Motilide polymorphs

Details Motilide polymorphs Motilide polymorphs

2010-04-16

2011-10-04

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S007400

Reexamination Certificate

active

08030282

ABSTRACT:
The invention provides polymorphs of a motilide having a structure represented by formula Ia

REFERENCES:
patent: 3855200 (1974-12-01), Krowicki et al.
patent: 3939144 (1976-02-01), Radobolja et al.
patent: 3983103 (1976-09-01), Kobrehel et al.
patent: 4588712 (1986-05-01), Toscano et al.
patent: 5008249 (1991-04-01), Omura et al.
patent: 5175150 (1992-12-01), Omura et al.
patent: 5444051 (1995-08-01), Agouridas et al.
patent: 5470961 (1995-11-01), Harada et al.
patent: 5523401 (1996-06-01), Freiberg et al.
patent: 5523418 (1996-06-01), Freiberg et al.
patent: 5538961 (1996-07-01), Freiberg et al.
patent: 5554605 (1996-09-01), Freiberg et al.
patent: 5561118 (1996-10-01), Agouridas et al.
patent: 5578579 (1996-11-01), Lartey et al.
patent: 5654411 (1997-08-01), Lartey et al.
patent: 5658888 (1997-08-01), Koga et al.
patent: 5712253 (1998-01-01), Lartey et al.
patent: 5770579 (1998-06-01), Agouridas et al.
patent: 5834438 (1998-11-01), Lartey et al.
patent: 5922849 (1999-07-01), Premchandran et al.
patent: 5959088 (1999-09-01), Miura et al.
patent: 6084079 (2000-07-01), Keyes et al.
patent: 6169168 (2001-01-01), Asaka et al.
patent: 2002/0025936 (2002-02-01), Ashley et al.
patent: 2002/0094962 (2002-07-01), Ashley et al.
patent: 2002/0192709 (2002-12-01), Carreras et al.
patent: 2004/0138150 (2004-07-01), Santi et al.
patent: 2005/0113319 (2005-05-01), Carreras et al.
patent: 2005/0119195 (2005-06-01), Carreras et al.
patent: 2005/0256064 (2005-11-01), Liu et al.
patent: 2006/0270616 (2006-11-01), Liu et al.
patent: 2007/0135362 (2007-06-01), Liu
patent: 2 402 200 (1974-07-01), None
patent: 1 416 281 (1975-12-01), None
patent: 1 461 032 (1977-01-01), None
patent: 60-218321 (1985-11-01), None
patent: 2002-241391 (2002-08-01), None
Satoshi Omura et al., “Gastrointestinal Motorstimulating Activity of Macrolide Antibiotics and the Structure-activity Relationship,” J. Antibiotics 1985, 38, 1631-32.
Ramin Faghih et al., “Preparation of 9-deoxo-4-deoxy-6,9-epoxyerythromycin Lactams “Motilactides”: Potent and Orally Active Prokinetic Agents,” Biorg. & Med. Chem. Lett., 1998, 8, 805-810.
Ramin Faghih et al., “Synthesis of 9-Deoxo-4-deoxy-6,9-epoxyerythromycin Derivatives: Novel and Acid-Stable Motilides,” J. Med. Chem., 1998, 41, 3402-3408.
Ramin Faghih et al., “Entry into Erythromycin Lactams: Synthesis of Erythromycin A Lactam Enol Ether as a Potential Gastrointestinal Prokinetic Agent,” Synlett., Jul. 1998, 751-53.
Paul A. Lartey et al., “Synthesis of 4-Deoxy Motilides: Identification of a Potent and Orally Active Prokinetic Drug Candidate,” J. Med. Chem., 1995,38,1793-98.
R. Ryden et al., “N-Substituted Derivatives of Erythromycylamine,” J. Med. Chem., 1973, 16(9), 1059-60.
Slawomir Naperty et al., “Erythromycin Derivatives. Part IX. Cyclic 8,9-Carbonate of 8-Hydroxyerythromycin B,” Roczniki Chemii, 1977, 51(6), 1207-10.
Richard S. Egan et al., “The Structures of the m-Chloroperbenzoic Acid Oxidation Products of 8,9-Anhydroerythromycins A- and B-6,9-Hemiacetal and of (8s)-8-Hydroxyerythromycin B,” J. Antibiotics, 1978, 31(1), 55-62.
P. Matijasevic et al., “Erythromycin Series. X. Inhibitory Activity of Several New Erythromycin Derivatives in Cell-Free Amino Acid Polymerization Systems,” Croatica Chemica Acta, 1980, 53(3), 519-24.
Gorjana Radobolja et al., “Erythromycin Series. IX. Acid Solvolysis of N-(4-Substituted-Benzenesulfonyl) Erythromycylamines,” Croatica Chemica Acta, 1985, 58(2), 219-25.
Eric Hunt et al., “9,11-Cyclic Acetal Derivatives of (9s)-9-Dihydroelythromycin A,” J. Antibiotics, 1989, 42(2), 293-98.
David C. Myles et al., “Development of a Fully Synthetic Stereoselective Route to 6-Deoxyerythronolide B by Reiterative Applications of the Lewis Acid Catalyzed Diene Aldehyde Cyclocondensation Reaction: A Remarkable Instance of Diastereofacial Selectivity,” J. Org. Chem., 1990, 55, 1636-48.
Gabrijela Kobrehel et al., “Erythromycin Series. VIII Synthesis and Biological Activity of N-(Substituted-benzenesulfonyl) Erythromycylamines,” Eur. J. Med. Chemistry, 1978, 13(1), 83-87.
N. K. Jain et al., “Polymorphism in Pharmacy,” 23(6) Indian Drugs 315-329 (Mar. 1986).
Mino R. Caira, “Crystalline Polymorphism of Organic Compounds,” 198 Topics in Current Chemistry 163-208 (1998).
S. R. Byrn et al., “Solid-state Pharmaceutical Chemistry,” 6 Chem. Mater. 1148-1158 (1994).
David J. W. Grant, Polymorphism in Pharmaceutical Solids, Chapter 1: Theory and Origin of Polymorphism, pp. 1-10 (1999).
J. Keith Guillory, Polymorphism in Pharmaceutical Solids, Chapter 5: Generation of Polymorphs, Hydrates, Solvates, and Amorphous Solids, pp. 183-226 (1999).
Notification of Defects in Israeli Patent Application No. 198449 (May 30, 2011).

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