Motif Libraries

Details Motif Libraries Motif Libraries

1996-11-22

1998-12-08

Green, Lora M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 71, 436501, 530333, 530334, G01N 3353

Patent

active

058468412

ABSTRACT:
The invention concerns libraries of chemical compounds, that are useful in medicinal chemistry and related arts, their methods of manufacture and methods of their use. In one embodiment the individual chemical species of the library are synthesized aleatoricly, i.e, by a process involving chance. The chemical species of the library are used while attached to solid phase supports. The library differs from previously disclosed libraries that were intended to be screened while in solid phase in that each individual solid phase support or identifiable portion of a solid phase array displays many species of ligands, collectively termed a "set." The library is constructed so that each set contains a single invariant structure, common to all the species of ligands attached to the particular solid phase support, which is termed a "motif." The invention teaches that libraries of motifs can be employed advantageously compared to known libraries wherein a single species is present on each support.

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