Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Reexamination Certificate
2007-03-13
2007-03-13
Rao, Manujunath N. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
C435S193000, C435S069100, C435S320100, C435S483000, C536S023200
Reexamination Certificate
active
11251466
ABSTRACT:
Lysophosphatidic acid acyltransferase (LPAAT) participates in the second step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids produced in oils of oleaginous organisms. The present application provides a nucleic acid fragment (identified as “LPAAT2”) isolated fromMortierella alpinaencoding a LPAAT homolog that is suitable for use in the manufacture of oils enriched in omega fatty acids in oleaginous organisms. Most desirably, the substrate specificity of the instant LPAAT2 will be particularly useful to enable accumulation of long-chain PUFAs having chain lengths equal to or greater than C20in oleaginous yeast, such asYarrowia lipolytica.
REFERENCES:
patent: 2005/0136519 (2005-06-01), Picataggio et al.
patent: WO 2004/087902 (2004-10-01), None
U.S. Appl. No. 10/840,579, filed May 6, 2004, Picataggio et al.
U.S. Appl. No. 60/624,812, filed Nov. 4, 2004, Zhu et al.
U.S. Appl. No. 11/265,761, filed Nov. 2, 2005, Zhu et al.
National Center for Biotechnology Information General Identifier No. 55163909, Accession No. CQ891250, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163911, Accession No. CQ891252, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 3914356, Accession No. Q93841, Feb. 7, 2006, Genome Sequence of the Nematode C. Elegans: A Platform for Investigating Biology.
National Center for Biotechnology Information General Identifier No. 3914366, Accession No. Q22267, Feb. 7, 2006, Genome Sequence of the Nematode C. Elegans: A Platform for Investigating Biology.
National Center for Biotechnology Information General Identifier No. 3914372, Accession No. Q99943, Feb. 7, 2006, J. West et al., Cloning and Expression of Two Human Lysophosphatidic Acid Acyltransferase cDNAS That Enhance Cytokine-Induced Signaling Response in Cells.
National Center for Biotechnology Information General Identifier No. 3914362, Accession No. O15120, Feb. 7, 2006, C. Eberhardt et al., Human Lysophosphatidic Acid Acyltransferase. cDNA Cloning, Expression, and Localization to Chromosome 9Q34.3.
National Center for Biotechnology Information General Identifier No. 12643817, Accession No. Q9NRZ7, Feb. 7, 2006, D. W. Leung.
National Center for Biotechnology Information General Identifier No. 12230468, Accession No. Q9NRZ5, Feb. 7, 2006, D. W. Leung.
National Center for Biotechnology Information General Identifier No. 30923427, Accession No. Q9NUQ2, Feb. 7, 2006, D. W. Leung.
National Center for Biotechnology Information General Identifier No. 3914383, Accession No. O35083, Feb. 7, 2006, K. Kume et al., CDNA Cloning and Expression of Murine.
National Center for Biotechnology Information General Identifier No. 30923346, Accession No. Q9D1E8, Feb. 7, 2006, B. Lu et al.
National Center for Biotechnology Information General Identifier No. 20138810, Accession No. Q924S1, Feb. 7, 2006, W. Li et al.
National Center for Biotechnology Information General Identifier No. 3914378, Accession No. Q59188, Feb. 7, 2006, C. M. Fraser et al. Genomic Sequence of a Lyme Disease Spirochaete, Borrelia Burgdorferi.
National Center for Biotechnology Information General Identifier No. 3914374, Accession No. Q42670, Feb. 7, 2006, D. S. Knutzon et al., Cloning of a Coconut Endosperm cDNA Encoding a 1-Acyl-SN-Glycerol-3-Phosphate Acyltransferase That Accepts Medium-Chain-Length Substrates.
National Center for Biotechnology Information General Identifier No. 130327, Accession No. P26647, Feb. 7, 2006, J. Coleman, Characterization of theEscherichia coliGene for 1-Acyl-SN-Glycerol-3-Phosphate Acyltransferase (PLSC).
National Center for Biotechnology Information General Identifier No. 1172534, Accession No. P44848, May 1, 2005, R. D. Fleischmann et al., Whole-Genome Random Sequencing and Assembly ofHaemophilus influenzaeRD.
National Center for Biotechnology Information General Identifier No. 12230506, Accession No. Q9ZJN8, May 1, 2005, R. A. Alm et al. Genomic-Sequence Comparison of Two Unrelated Isolates of the Human Gastric PathogenHelicobacter pylori.
National Center for Biotechnology Information General Identifier No. 3914373, Accession No. O25903, May 1, 2005, J. -F. Tomb et al., The Complete Genome Sequence of the Gastric PathogenHelicobacter pylori.
National Center for Biotechnology Information General Identifier No. 3914375, Accession No. Q42868, Feb. 7, 2006, M. W. Lassner et al., Lysophosphatidic Acid Acyltransferase from Meadowfoam Mediates Insertion of Erucic Acid at the SN-2 Position of Triacylglycerol in Transgenic Rapeseed Oil.
National Center for Biotechnology Information General Identifier No. 3914376, Accession No. Q42870, Feb. 7, 2006, C. Hanke et al., A Plant Acyltransferase Involved in Triacylglycerol Biosynthesis Complements anEscherichia coliSN-1-Acylglycerol-3-Phosphate Acyltransferase Mutant.
National Center for Biotechnology Information General Identifier No. 130329, Accession No. P26974, May 1, 2005, A. L. Luttinger et al., A Cluster of Genes That Affects Nucleoid Segregation in Salmonella Typhimurium.
National Center for Biotechnology Information General Identifier No. 464422, Accession No. Q33333, Feb. 7, 2006, M. M. Nagiec et al., A Suppressor Gene That EnablesSaccharomyces cerevisiaeto Grow Without Making Sphingolipids Encodes a Protein That Resembles anEscherichia coliFatty Acyltransferase.
National Center for Biotechnology Information General Identifier No. 83287830, Accession No. Q9XFW4, Feb. 7, 2006, A. Graefin Zu Muenster et al.
National Center for Biotechnology Information General Identifier No. 55163919, Accession No. CQ891260, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163917, Accession No. CQ891258, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163907, Accession No. CQ891248, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163904, Accession No. CQ891245, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163900, Accession No. CQ891241, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163897, Accession No. CQ891238, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163913, Accession No. CQ891254, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 55163894, Accession No. CQ891235, Nov. 1, 2004, A. Renz et al., Novel Plant Acyltransferases Specific for Long-Chained, Multiply Unsaturated Fatty Acids.
National Center for Biotechnology Information General Identifier No. 49649227, Accession No. CR382131, Nov. 9, 2005, B. Dujon et al., Genome Evolution in Yeasts.
National Center for Biotechnology Information General Identifier No. 49646199, Accession No. CR382128, Nov. 9, 2005, B. Dujon et al., Genome Evolution in Yeasts.
Damude Howard Glenn
Xue Zhixiong
E. I. du Pont de Nemours and Company
Rao Manujunath N.
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