Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2007-03-20
2007-03-20
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C435S069100, C435S257200, C435S254110, C435S254200, C435S320100, C435S254220, C435S193000, C536S023200
Reexamination Certificate
active
11254173
ABSTRACT:
Glycerol-3-phosphate o-acyltransferase (GPAT) participates in the first step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids (PUFAs) produced in oils of oleaginous organisms. The present application provides a nucleic acid fragment isolated fromMortierella alpinaencoding a GPAT that is suitable for use in the manufacture of oils enriched in omega fatty acids in oleaginous organisms. Most desirably, the substrate specificity of the instant GPAT will be particularly useful to enable accumulation of long-chain PUFAs having chain lengths equal to or greater than C20in oleaginous yeast, such asYarrowia lipolytica.
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Sanjay Mishra et al., Purification and Characterization of Thiol-Reagent-Sensitive Glycerol-3-Phosphate Acyltransferase from the Membrane Fraction of an Oleaginous Fungus. Biochem. J., vol. 355:315-322, 2001.
James O. Hill et al., Environmental Contributions to the Obesity Epidemic, Science, vol. 280:1371-1374, 1998.
Robert M. Bell et al., Enzymes of Triacylglycerol Formation in Mammals, the Enzymes, vol. 26:87-111, 1983.
Lori Dircks et al., Acytransferases of De Novo Glycerophospholipid Biosynthesis. Progress in Lipid Research, vol. 38:461-479, 1999.
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National Center for Biotechnology Information General Identifier No. 50257380, Accession No. EAL20089, Jul. 13, 2004, E. Fung et al., Cryptococcus Neoformans Serotype D Sequencing.
National Center for Biotechnology Information General Identifier No. 46099004, Accession No. EAK84237, Apr. 2, 2004, B. Birren et al.
Sanjay Mishra et al., Purification and Characterization of Thiol-Reagent-Sensitive Glycerol-3-Phosphate Acyltransferase From the Membrane Fraction of an Oleaginous Fungus, Biochem. J., vol. 355:315-322, 2001.
James O. Hill et al., Environmental Contributions to the Obesity Epidemic, Science, vol. 280:1371-1374, 1998.
Robert M. Bell et al., Enzymes of Triacylglycerol Formation in Mammals, the Enzymes. vol. 26:87-111, 1983.
Lori Dircks et al., Acyltransferases of De Novo Glycerophospholipid Biosynthesis. Progress in Lipid Research. vol. 38:461-479. 1999.
Macool Daniel Joseph
Xue Zhixiong
Chowdhury Iqbal
E. I. du Pont de Nemours and Company
Prouty Rebecca E.
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