Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-03-18
1997-05-06
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 721, 436 63, 436 64, 436813, G01N 33574
Patent
active
056270399
ABSTRACT:
The intracellular distribution of mortalin is used to determine the complementation group of tumor cells. Also disclosed are the gene sequences that encode mortalin and the amino acid sequence of the mortalin proteins.
REFERENCES:
Wadhwa, et al., Experimental Cell Research, vol. 216, No. 1, pp. 101-106, 1995.
Pereira-Smith, O.M. et al., " Genetic Analysis of Indefinite Division in Human cells: Identification of Four Complementation Groups," Proc. Natl. Acad. Sci. (U.S.A.) 85:6042-6046 (1988).
Ning, Y. et al., "Tumor Suppression by Chromosome 11 Is Not Due to Cellular Senescence," Exper. Cell Res. 192:220-226 (1991).
Ning, Y. et al., "Molecular Genetic Approaches to the Study of Cellular Senescence," Mutat. Res. 256:303-310 (1991).
Spiering, A.L. et al., "Correlation Between Complementation Groups for Immortality and DNA Synthesis Inhibitors," Exper. Cell Res. 195:541-545 (1991).
Ning, Y. et al., "Genetic Analysis of Indefinite Division in Human Cells: Evidence for a Cell Senescence-Related Gene(s) on Human Chromosome 4," Proc. Natl. Acad. Sci. (U.S.A.) 88:5635-5639 (1991).
Kwok, P.Y. et al., "Automatable Screening of Yeast Artificial-Chromosome Libraries Based on The Oligonucleotide-Ligation assay," Genomics 13:935-941 (1992).
Drebin, J.A. et al., "Tumor Markers In Cancer Diagnosis and Therapy," In: Current Therapy in Oncology, (Niederhuber, J.E., Ed.) B.C. Decker, pp. 58-61 (1993).
Wadhwa R. et al., "Protein Markers for Cellular Mortality and Immortality," Mutat. Res. 256:243-254 (1991).
Wadhwa, R. et al., "Differential Subcellular Distribution in mortal and Immortal Mouse and Human Fibroblasts," Exper. Cell Res. 207:442-448 (Aug. 1993).
Wadhwa, R. et al., "Induction of Cellular Senescence by Transfection of Cytosolic Mortalin cDNA in NIH 3T3 Cells," J. Biol. Chem. 268:22239-22242 (Oct. 1993).
Wadhwa, R. et al., "Spontaneous Immortalization of Mouse Fibroblasts Involves Structural Changes in Senescence Inducing Protein, Mortalin," Biochem. Biophys. Res. Commun. 197:202-206 (Dec. 1993).
Wadhwa, R. et al., "Identification of a Novel Member of Mouse hsp70 Family," J. Biol. Chem. 268:6615-6621 (Mar. 1993).
Pereira-Smith Olivia M.
Wadhwa Renu
Baylor College of Medicine
Scheiner Toni R.
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