Morpholinocarbonyl alkyl N-benzylpiperazines

Details Morpholinocarbonyl alkyl N-benzylpiperazines Morpholinocarbonyl alkyl N-benzylpiperazines

1977-05-03

1978-05-23

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

542470, 42424854, 42424856, 424250, 544365, 544402, 544400, 544391, 544401, 544390, C07D41302

Patent

active

040912205

ABSTRACT:
Novel N-benzylpiperazine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are same or different and each stands for a hydrogen atom or an acyl group; R.sup.3 stands for a hydrogen atom; a carbamoyl group, an acyl group which is unsubstituted or substituted by mercapto or morpholino, or an alkyl group which is unsubstituted or substituted by hydroxy, aryl or aminocarbonyl represented by the formula ##STR2## wherein each of R.sup.4 and R.sup.5 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or a cyclohexyl group, or R.sup.4 and R.sup.5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X stands for a halogen atom, and pharmaceutically acceptable acid addition salts thereof. These compounds and salts thereof have respiratory tract fluid secretion stimulatory properties and are useful as medicines such as respiratory track fluid secretion stimulators.

REFERENCES:
ishiguro et al., "Chem Abstracts" vol. 85, (1976) No. 94405r.

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