Morpholino-terminated non-peptidyl .alpha.-succinamidoacyl amino

Details Morpholino-terminated non-peptidyl .alpha.-succinamidoacyl amino Morpholino-terminated non-peptidyl .alpha.-succinamidoacyl amino

1991-07-19

1995-05-30

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142288, 5142308, 544 88, 544 97, 544163, 544168, A61K 31535, C07D26506, C07D26532, C07D295182

Patent

active

054201276

ABSTRACT:
Non-peptidyl compounds characterized generally as .alpha.-succinamidoacyl aminodiols having a morpholino-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.

REFERENCES:
Umezawa, et al, The Journal of Antibiotics (Tokyo) 23, pp. 259-262 (1970).
Gross, et al, Science, 175, p. 656 (1971).
Boger, et al, Nature, 303, pp. 81-84 (1983).
Kokubu, et al, Biochem. Biophys. Research Commun., 118, pp. 929-933 (1984).
Fehrentz, et al, FEBS Lett., 167, pp. 273-276 (1984).
Hanson, et al, Biochem. Biophys. Research Commun., 132, pp. 155-161 (1985).
Hanson, et al, Biochem. Biophys. Research Commun., 146, pp. 959-963 (1987).
Marshall, Federation Proceedings, 35, pp. 2494-2501 (1976).
Burton, et al, Proc. Natl. Acad. Sci. USA, 77, pp. 5476-5479 (1980).
Suketa, et al, Biochemistry, 14, pp. 3188-3194 (1975).
Swales, Pharma. Ther., 7, pp. 173-201 (1979).
Kokubu et al, Nature, 217, pp. 456-457 (1968).
Matsushita, et al, The Journal of Antibiotics, 28, pp. 1016-1018 (1975).
Lazar, et al, Biochem. Pharma., 23, pp. 2776-2778 (1974).
Miller, et al, Biochem. Pharma, 21, pp. 2941-2944 (1972).
Haber, Clinical Science, 59, pp. 7s-19s (1980).
Rich, et al, J. Org. Chem., 43, pp. 3624-3626 (1978).
Rich, et al, J. Med. Chem., 23, pp. 27-33 (1980).
Haber, Clin. and Exper. Hyper., A5(7&8), pp. 1193-1205 (1983).

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