Morpholino-subunit combinatorial library and method

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528398, 528399, 528403, 528405, 528406, 528422, 528423, 528425, C07D41312, C07D41314, C08G 5900, C08G 6500

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055063373

ABSTRACT:
A method of generating a compound capable of interacting specifically with a selected macromolecular ligand is disclosed. The method involves contacting the ligand with a combinatorial library of oligomers composed of morpholino subunits with a variety of nucleobase and non-nucleobase side chains. Oligomer molecules that bind specifically to the receptor are isolated and their sequence of base moieties is determined. Also disclosed is a combinatorial library of oligomers useful in the method and novel morpholino-subunit polymer compositions.

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