Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino

Details Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino

1992-08-14

1995-06-06

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142308, 5142378, 5142382, 544 88, 544 97, 544163, 544168, A61K 31535, C07D26506, C07D29500

Patent

active

054223490

ABSTRACT:
Compounds characterized generally as morpholino/oxazinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein B is selected from morpholino, oxo-substituted-morpholino and 1,3-oxazinyl groups; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from

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