Morpholin-acetamide derivatives for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S170000

Reexamination Certificate

active

07101882

ABSTRACT:
The present invention relates to novel morpholin-acetamide compounds of formula (I) useful for the treatment of inflammatory diseases. Compounds of formula (I)wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

REFERENCES:
patent: 0243959 (1987-11-01), None
patent: 0 243 959 (1992-08-01), None
patent: 0 760 362 (1997-03-01), None
patent: 0 903 349 (1999-03-01), None
patent: 2 785 902 (1999-11-01), None
patent: 1 117882 (1989-05-01), None
patent: 4 208267 (1992-07-01), None
patent: 9637486 (1996-11-01), None
patent: WO 97 48397 (1997-12-01), None
patent: 9748695 (1997-12-01), None
patent: WO 99 55324 (1999-11-01), None
patent: WO 00 04003 (2000-01-01), None
patent: WO 00 27800 (2000-05-01), None
patent: WO 00 27835 (2000-05-01), None
patent: WO 00 27843 (2000-05-01), None
patent: WO 00 29377 (2000-05-01), None
patent: WO 00 31032 (2000-06-01), None
patent: WO 00 31033 (2000-06-01), None
patent: WO 00 34278 (2000-06-01), None
patent: WO 00/35449 (2000-06-01), None
patent: WO 00 35451 (2000-06-01), None
patent: WO 00 35452 (2000-06-01), None
patent: WO 00 35453 (2000-06-01), None
patent: WO 00 35454 (2000-06-01), None
patent: WO 00 35876 (2000-06-01), None
patent: WO 00 35877 (2000-06-01), None
patent: WO 00 41685 (2000-07-01), None
patent: WO 00 51607 (2000-09-01), None
patent: WO 00 51608 (2000-09-01), None
patent: WO 00 53172 (2000-09-01), None
patent: WO 00 53600 (2000-09-01), None
patent: 0071518 (2000-11-01), None
patent: WO 00 71518 (2000-11-01), None
patent: WO 01 14333 (2001-03-01), None
Kato, Shiro, et. al., “Novel Benzamides as Selective and Potent Gastric Prokinetic Agents. 1. Synthesis and Structure-Activity Relationships of N-[(2-Morpholinyl)alkyl]benzamides,”J. Med. Chem., 1990, vol. 33, pp. 1406-1413.
Wells and Schwartz, “Plagiarism of the host immume system: lessons about chemokine immunology from viruses,”Curr.Opin.Biotech, 1997, vol. 4, pp. 741-748.
Choe, Hyeryun, The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates,Cell. vol. 85, pp. 1135-1148, Jun. 28, 1996.
Luster, Andrew D., M.D., PH.D., “Chemokines—Chemotactic Cytrokines That Mediate Inflammation,”The New England Journal of Medicine, 1998, vol. 338, pp. 436-445.
Gonzalo, Jose-Angel, “the Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness,”J. Exp. Med., 1998, vol. 188, pp. 157-167.
Heath, Heidi, “Chemokine Receptor Usage by Human Eosinophils,”J. Clin. Invest., 1997, vol. 99 (2), pp. 178-184.
Lloyd, Clare M., et. al., “CC Chemokine Receptor (CCR)3/Eotaxin Is Followed by CCR4/Monocyte-derived Cehmokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge In Vitro,”J.Exp.Med., 2000, vol. 191 No. 2, pp. 265-273.
Griffiths-Johnson, et. al., “Eotaxin: A Potent Eosinophil Chemoattractant Cytokine Detected in Guinea Pig Model of Allergic Airways Inflammation,”J. Exp. Chem., 1994, vol. 179, pp. 881-887.
Kato, et. al., “Novel benzamides as selective and potent gastrokinetic agents”,Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, vol. 40, No. 3, 1992, 652-660.
Kato, et. al., “Novel benzamides as selective and potent gastrokinetic agents”,Journal of Medicinal Chemistry, American Chemical Society, vol. 34, No. 2, 1991, 616-624.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Morpholin-acetamide derivatives for the treatment of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Morpholin-acetamide derivatives for the treatment of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Morpholin-acetamide derivatives for the treatment of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3613321

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.