Morphogen treatment of organ implants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 8, 514 12, A61K 3816, A61K 3817, A61K 3818

Patent

active

060907762

ABSTRACT:
The present invention is directed to methods and compositions for enhancing viability of organs and living tissues to be transplanted in a mammal. The methods and compositions provide a therapeutically effective concentration of a morphogen or morphogen-stimulating agent to the tissue or organ to be transplanted, sufficient to substantially protect the tissue or organ from tissue damage.

REFERENCES:
patent: 4388309 (1983-06-01), Fibricius et al.
patent: 4450159 (1984-05-01), Anderson et al.
patent: 4473637 (1984-09-01), Guibert
patent: 4877864 (1989-10-01), Wang et al.
patent: 4968590 (1990-11-01), Kuberasampath et al.
patent: 4971952 (1990-11-01), Bentz et al.
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 5002965 (1991-03-01), Ramwell et al.
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5108753 (1992-04-01), Kuberasampath et al.
patent: 5118791 (1992-06-01), Burnier et al.
patent: 5135915 (1992-08-01), Czarniecki et al.
patent: 5141905 (1992-08-01), Rosen et al.
Noda et al. Endocrinology 124:2991-2994, 1989.
Joyce et al. Annals of the New York Academy of Sciences 593:107-123, 1990.
Beck et al. J. Bone Min. Res. 6:1257-1265, 1991.
Puolakkainen et al. J. Surg. Res. 58:321-329, 1995.
Alberts et al., Molecular Biology of the Cell, 3rd edition, Garland Publishing Inc., New York, p. 937, 1994.
Sampath et al. (1983), "Homology of Bone-Inductive Proteins From Human, Monkey, Bovine and Rat Extracellular Matrix," 80 Proc. Nat'l Acad. Sci. USA 6591-6595.
Bentz et al. (1987), "Cartilage Induction and Differentiation: The Role of Bone Derived Cartilage Inducing Factor (CIF-A)," Dev. & Diseases of Cartil. & Bone Matrix 137-147.
Ruscetti et al. (1991), "Transforming Growth Factor-.beta. And The Immune System," 3 Prog. Growth Factor Res. 159-175.
Sporn et al. (1992), "Transforming Growth Factor-.beta.: Recent Progress and New Challenges," 119 J. Cell Biol. 1017-1021.
Gross et al. (1993), "Transforming Growth Factor-.beta.1 Reduces Infarct Size After Experimental Cerebral Ischemia in a Rabbit Model," 24 Stroke 558-562.
Reddi et al. (1993), "Initiation and Promotion of Bone Differentiation by Bone Morphogenetic Proteins," 8 J. Bone. Min. Res. 2:S499-S502.
Sampath et al. (1994), "Structure, Function, and Orthopedic Applications of Osteogenic Protein-1 (OP-1)," Complications in Orthop. 101-107.
Behringer et al., Nature, 345:167-170 (1990).
Cate et al., Cell, 45:685-698 (1986).
Celeste et al., PNAS, 87:9843-9847 (1991).
Chomczyaski et al., Anal. Biochem, 162:156-159 (1987).
Green et al., Nature, 347:391-394 (1990).
Kuberasampath et al., J. Biol. Chem., 265:13198-13205 (1990).
Lee, Molecular Endocrinology, 90:1034-1040 (1990).
Lee, PNAS, 88:4250-4254 (1991).
Lyons et al., PNAS, 86:4554-4558 (1989).
Lyons et al., Genes & Development, 3:1657-1668 (1989).
Mason et al., Nature, 318:659-663 (1985).
Mason et al., Mol. Endocrinology, 3:1352-1358 (1989).
Miller et al., Cancer Research, 42:2589-3594 (1987).
Ozkaynak et al., Embo J., 9:2085-2093 (1990).
Ozkaynak et al., Biochem. Biophys. Res. Comm., 179:116-123 (1991).
Padgett et al., Nature, 325:81-84 (1987).
Panganiban et al., Mol. and Cell. Biol., 10:2669-2677 (1990).
Sampath et al., PNAS, 80:6591-6595 (1983).
Schubert et al., Nature, 344:868-870 (1990).
Smith et al., Nature, 345:729-731 (1990).
Sokol et al., Science, 249:561-563 (1990).
Wang et al., PNAS, 87:2220-2224 (1990).
Wang et al., PNAS, 85:9484-9488 (1988).
Weeks, Cell, 51:861-867 (1987).
Wharton et al., PNAS, 88:9214-9218 (1991).
Wozney et al., Science, 242:1528-1534 (1988).
Yannas, Angew. Chem. Int. Ed. Engl., 29:20-35 (1990).
Rosen et al., Wang et al., and Wozney et al., "Development Expression of Cartilage and E-Specific Genes in the Rat Embryo", "Identification Through Molecular Cloning of Factors Involved in In Vivo Cartilage Formation", Calcified Tissue Int, 42 (Suppl.): A35(136), A37(146,147) 3 Abstracts (1988).
Rosen et al., "Purification and Molecular Cloning of a Novel Group of BMPS and Localization of BMP MRNA in Developing Bone", Connect Tissue Res, 20(1-4): 313-9.
Wozney et al., "Bone Morphogenetic Proteins", Progress In Growth Factor Research, 1: 267-280 (1990).
2 Abstracts, Rosen et al., "In Vivo and In Vitro Roles of BMP in Skeletal Formation and Repair", and Celeste et al., "Highly Purified Bovine Bone-Inductive Activity Contains Multiple Protein Species Related to BMP-2", J Cell Biochem Suppl. 0 (14 Part E): 33(004), 54(105) (1990).
Katagiri et al., "The Non-Osteogenenic Mouse Pluripotent Cell Line, C3H10T1/2, is Induced to Differentiate Into Osteoblastic Cells by Recombinant Human Bone Morphogenetic Protein-2", Biochem. Biophys Res, (172, (1): 295-299 (1990).
Wozney et al., "Growth factors influencing bone development", Journal of Cell Science Suppl., 13: 149-156 (1990).
Celeste et al., "Identification of transforming growth factor .beta. family members present in bone-inductive protein purified from bovine bone", PNAS, 87: 9843-9847 (1990).
Takuwa et al., "Bone Morphogenetic Protein-2 Stimulates Alkaline Phosphatase Activity and Collagen Synthesis in Cultured Osteoblastic Cells, MC3T3-E1", Biochem Biophys Res Comm, 174(1):96-101 (1991).
Yamaguchi et al., "Recombinant Human Bone Morphogenetic Protein-2 Stimulates Osteoblastic Maturation and Inhibits Myogenic Differentiation In Vitro", J Cell Biol, 113 (3): 681-7 (1991).
Abstract Q-105 D'Alessandro et al., "Purification Characterization and Activity of Recombinant Human BMP-5", Journal of Cellular Biochemistry, (1991).
Abstract Q-111, Israel et al., "Expression of Recombinant BMP2 in Chinese Hamster Ovary Cells", Journal of Cellular Biochemistry, (1991).
Thies et al., "Recombinant Human Bone Morphogenetic Protein-2 Induces Osteoblastic Differentiation in W-20-17 Stromal Cells", Endocrinology, 130(3):1318-1324 (1992).
Wozney et al., "The Bone Morphogenetic Protein Family and Osteogenesis", Mol Reprod Dev, 32 (2): 160-167 (1992).
Rogers et al., "Bone Morphogenetic Proteins-2 and -4 are Involved in the Retinoic Acid-Induced Differentiation of Embryonal Carcinoma Cells", Mol Biol Cell, 3 (2): 289-196 (1992).
3 Abstracts, Rosen et al., "Isolation and Characterization of BMP-Responsive Cartilage and Bone Cell Progenitors From Mouse Embryo Limb Buds", Celeste et al., "Molecular Cloning of BMP-8: A Protein Present in Bovine Bone Which is Highly Related to the BMP-5/6/7 Subfamily of Osteoinductive Molecules", and Wozney et al., "Regulation of Chondrogenesis and Osteogenesis by the BMP Proteins", J Cell Biochem Suppl, 0 (16 Part F): 103(W513); 100(W502): 76(W026) (1992).
Israel et al., "Expression and Characterization of Bone Morphogenetic Protein-2 in Chinese Hamster Ovary Cells", Growth Factors, 7: 139-150 (1992).
Padgett et al., "Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embyro", Proce. Natl. Acad. Sci. USA, 90: 2905-2909 (1993).
Bowie et al. 1990. Science 247: 1306-1310.
Ngo et al. 1994. The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., eds., pp. 491-495., Birkhauser Press, Boston.
George et al. (1988) Macromolecular Sequencing and Synthesis (Alan R. Liss, Inc., N.Y) pp. 127-149.
Gennaro (1990) Remington's Pharmaceutical Sciences (Mack Pubs., N.Y.).
Lefer et al. (1990) Science 249: 61-64.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Morphogen treatment of organ implants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Morphogen treatment of organ implants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Morphogen treatment of organ implants will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2037141

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.