Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1996-10-08
1999-07-27
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
435 6, 435 71, 4353201, 536 235, 536 2431, 935 9, 935 66, C12N 500, C12N 1500, C07H 2104
Patent
active
059289406
ABSTRACT:
A novel gene, DD-10, and its encoded polypeptide chain, DD-10, expressed during early onset of morphogen-induced mammalian tissue morphogenesis, now has been discovered. Accordingly, the invention identifies a new gene which is a novel biological marker of cell differentiation and tissue morphogenesis, particularly of chondroblast or osteoblast cell differentiation and bone tissue morphogenesis. Disclosed are: (a) methods and compositions for screening for and producing morphogen analogs; (b) novel morphogen analogs; (c) downstream inducers of morphogenesis; (d) a novel marker for evaluating morphogen or morphogen analog dosing; and (e) therapeutic methods and compositions using these analogs and/or downstream inducers.
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Ichijo Hidenori
Sampath Kuber T.
Takeda Kohsuke
Campell Bruce R.
Creative BioMolecules, Inc.
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