Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-07-26
1999-08-03
Kemmerer, Elizabeth
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 435325, 435 691, 435455, C12N 1511, C12N 1512
Patent
active
059327162
ABSTRACT:
Disclosed herein are methods and compositions for identifying morphogen analogs. Preferred methods rest on the use of test cells comprising DNA defining a morphogen-responsive transcription activating element operatively associated with a reporter gene. In certain embodiments, the methods involve an osteogenic protein 1 (OP-1) responsive transcription activating element. Substances that activate the OP-1 responsive transcription activating element are considered herein likely to be useful for reproducing in vivo effects of morphogens such as OP-1.
REFERENCES:
patent: 5023179 (1991-06-01), Lam et al.
Harada et al. (1995), "Characterization of the Osteogenic Protein-1 Response Region In The Type X Collagen Promoter," Abstract 124 Bone 17(6):590.
Harada et al. (1995), "Identification of an AP1 Like Response Region For Osteogenic Protein-1 In Type X Collagen Promoter," Abstract Distributed at New York Academy Sciences, Molecular and Developmental Biology of Cartilage, Sep. 27-30, 1995.
Harada et al. (1995), "Identification of an AP1 Like Response Region For Osteogenic Protein-1 In Type X Collagen Promoter," Abstract, New York Academy Sciences, Molecular and Developmental Biology of Cartilage, Sep. 27-30, 1995.
Elima et al. (1993), "The Mouse Collagen X Gene: Complete Nucleotide Sequence, Exon Structure and Expression Pattern," 289 Biochem. J. 1:247-253.
Harada et al. (1995), "Characterization of the Osteogenic Protein-1 Response Region In The Type X Collagen Promoter," Sixth Workshop On Cells and Cytokines In Bone and Cartilage, Davos, Switzerland, Jan. 7-10, 1996, 17 Bone (New York) 6:124.
Harada et al. (1995), "Identification of An AP1-Like Response Region For Osteogenic Protein-1 In Type X Collagen Promoter," Annals of The New York Academy of Sciences, No. 785, Molecular and Developmental Biology of Cartilage Conference, Bethesda, Maryland, USA, Sep. 27-30, 1995.
Harada et al. (1995), "Characterization of the Osteogenic Protein-1 Response Element In The Type X Collagen Promoter," Thirty-Fifth Annual Meeting of the American Society For Cell Biology, Washington, D.C., Dec. 9-13, 1995, Molecular Biology of the Cell 6 (Suppl.) 393 A.
Maliakal et al. (1994), "Osteogenic Protein-1 (BMP-7) Inhibits Cell Proliferation and Stimulates the Expression of Markers Characteristic of Osteoblast Phenotype In Rat Osteosarcoma (17/2.8) Cells," 11 Growth Factors 3:227-234.
Vukicevic et al. PNAS USA 93:9021-9026, Aug. 1996.
Reddi et al. J Bone Min. Res. 8:S499-S502, 1993.
Wozney et al. Handbook of Experimental Pharmacology, vol. 107, Mundy et al., eds., Springer-Verlag, Berlin, pp. 725-748, 1993.
Ngo et al. The Protein Folding Problem and tertiary Structure Prediction, Merz et al., eds., Birkhauser, Boston, pp. 491-495, 1994.
Wells. Biochemistry 29:8509-8579, 1990.
Bowie et al. Science 247:1306-1310, 1990.
Struhl et al. Cell 57:1259-1273, 1989.
Ozkaynak et al. EMBO J 9:2085-2093, 1990.
Michiels et al. (1993), "Retroviruses and Oncogenes Associated With Osteosarcomas," Osteosarcoma In Adolescents and Young Adults G. Bennett Humphrey (ed.), Kluwer Academic Publishers, Boston, MA.
Liu et al. (1994), "Simultaneous Detection of Multiple Bone-Related mRNAs and Protein Expression During Osteoblast Differentiation: Polymerase Chain Reaction and Immunocytochemical Studies At The Single Cell Level," 166 Dev. Biol. 220-234.
Rosen et al. (1994), "Responsiveness of Clonal Limb Bud Cell Lines to Bone Morphogenetic Protein 2 Reveals a Sequential Relationship Between Cartilage and Bone Cell Phenotypes," 9 J. Bone & Min. Res. 1759-1768.
Strong et al. (1994), "The Effects of the Insulin-Like Growth Factors and Transforming Growth Factor .beta. on the Jun Proto-Oncogene Family in MC3T3-E1 Cells," 55 Calcif. Tissue Int. 311-315.
Carey et al. (1995), "Expression of Bone Morphogenetic Protein-6 Messenger RNA in Bovine Growth Plate Chondrocytes of Different Size," 10 J. Bone & Min. Res. 3:401-405.
Chen et al. (1995), "Osteogenic Protein-1 Promotes Growth and Maturation of Chick Sternal Chondrocytes in Serum-Free Cultures," 108 J. Cell Sci. 105-114.
Sassone-Corsi (1995), "Signaling Pathways and c-fos Transcriptional Response--Links to Inherited Diseases," 332 N.E. J. Med. 23:1576-1577.
Harada et al. (1995), "Induction of Vascular Endothelial Growth Factor by Osteogenic Protein 1 in vitro and in vivo," Am. Soc. Bone & Min. Res. Abstract (will appear in Aug. issue); Abstract distributed by publisher on Jul. 28, 1995.
Harada et al. (1995), "Osteogenic Protein 1 Stimulates Type X Collagen Promoter Via A Fos Family Protein," Am. Soc. Bone & Min. Res. Abstract (will appear in Aug. issue); Abstract distruted by publisher on Jul. 28, 1995.
Lee et al. (1987), "Purified Transcription Factor AP-1 Interacts with TPA-Inducible Enhancer Elements," 49 Cell 741-752.
Ohta et al. (1992), "Bone Morphogenetic Proteins (BMP-2 and BMP-3) Induce the Late Phase Expression of the Proto-Oncogene c-fos in Murine Osteoblastic MC3T3-E1 Cells," 314 FEBS 3:356-360.
Wang et al. (1992), "Bone and Haematopoietic Defects in Mice Lacking c-fos," 360 Nature 741-745.
Asahina et al. (1993), "Human Osteogenic Protein-1 Induces Both Chondroblastic and Osteoblastic Differentiation of Osteoprogenitor Cells Derived From Newborn Rat Calvaria," 123 J. Cell Biol. 4:921-933.
Chen et al. (1993), "Bovine Articular Chondrocytes Do Not Undergo Hypertrophy When Cultured In the Presence of Serum and Osteogenic Protein-1," 197 Biochem. & Biophys. Res. Commun. 3:1253-1259.
Elima et al. (1993), "The Mouse Collagen X Gene: Complete Nucleotide Sequence, Exon Structure and Expression Pattern," 289 Biochem. J. 247-253.
Lovell et al. (1993), "Bone Morphogenetic Proteins Increase Type X Collagen Synthesis in vivo," J. Cell. Biochem. Abstract No. 17E:166.
Vainio et al. (1993), "Identification of BMP-4 as a Signal Mediating Secondary Induction Between Epithelial and Mesenchymal Tissues During Early Tooth Development," 75 Cell 45-58.
Harada et al. (1995), "Characterization of the Osteogenic Protein-1 Response Element in the Type X Collagen Promoter," 6 Mol. Biology of the Cell. Suppl. p. 393a, Abstract No. 2284.
Creative BioMolecules, Inc.
Kemmerer Elizabeth
LandOfFree
Morphogen-responsive regulatory elements does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Morphogen-responsive regulatory elements, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Morphogen-responsive regulatory elements will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-850533