Morphine sulphate microgranules, method for preparing same...

Details Morphine sulphate microgranules, method for preparing same... Morphine sulphate microgranules, method for preparing same...

2006-06-20

2006-06-20

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S489000

Reexamination Certificate

active

07063864

ABSTRACT:
The present invention concerns a novel sustained-release oral formulation of morphine sulphate in the form of microgranules. Each microgranule comprises a neutral support grain coated with an active layer and with a sustained-release layer, characterized in that the sustained-release layer contains a copolymer of methacrylic acid and of methyl methacrylate ester, the relative proportion of the free carboxyl groups and of the ester groups of which is equal to 0.5 approximately, and a silica exhibiting a hydrophobic character. The present invention also concerns a process for preparing these microgranules which is carried out entirely in aqueous medium by emplacing on neutral support grains.

REFERENCES:
patent: 5445829 (1995-08-01), Paradissis et al.
patent: 5672360 (1997-09-01), Sackler et al.
patent: 6077544 (2000-06-01), Debregeas et al.
patent: 0 205 282 (1986-05-01), None
patent: 0 609/961 (1990-01-01), None
patent: 0 377 518 (1990-07-01), None
patent: 0 553 392 (1992-08-01), None
patent: 0636 366 (1994-07-01), None
patent: 0 647 448 (1995-04-01), None
patent: 2 771 291 (1999-05-01), None
patent: WO 94/22431 (1994-10-01), None
patent: WO 95/31972 (1995-11-01), None
patent: WO 96/00066 (1996-01-01), None
patent: WO 96/14059 (1996-05-01), None

Affiliated with

Also associated with

Rating

Morphine sulphate microgranules, method for preparing same... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Morphine sulphate microgranules, method for preparing same..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Morphine sulphate microgranules, method for preparing same... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3665836