Morphine/apomorphine rearrangement process

Details Morphine/apomorphine rearrangement process Morphine/apomorphine rearrangement process

1978-05-18

1979-07-24

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21514

Patent

active

041623614

ABSTRACT:
Apomorphine derivatives are prepared in improved yield by rearrangement of the corresponding morphine derivative in the presence of anhydrous orthophosphoric acid under a partial vacuum and hydrolysis of the resulting phosphate esters in an aqueous medium.

REFERENCES:
small et al., J. Org. Chem., 5, pp. 334-349, 1940.

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