Morphinane-skeletoned hydrazone derivatives

Details Morphinane-skeletoned hydrazone derivatives Morphinane-skeletoned hydrazone derivatives

1992-10-06

1993-08-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 45, 546 46, C07D48908, A61K 31485

Patent

active

052329267

ABSTRACT:
The present invention relates to novel morphinane-skeletoned compounds of the formula (I) ##STR1## wherein Y in-NH phenyl or --NH dintro phenyl, Z is --CH.sub.2 -- CH.sub.2, R.sub.2 is hydroxyl and R.sub.3 is H or methyl, the steric isomers and the pharmaceutically acceptable salts thereof, a novel process for producing the same and pharmaceutical compositions comprising the same as active ingredients.
The novel compounds can be used in the therapy as analgetic or morphine-antagonistic agents.

REFERENCES:
patent: 2797221 (1957-06-01), Gates, Jr.
patent: 4608376 (1986-08-01), Pasternak
patent: 4678779 (1987-07-01), Meyers et al.
patent: 4730048 (1988-03-01), Portoghese
patent: 4803208 (1989-02-01), Pasternak
patent: 4806556 (1989-02-01), Portoghese
Borsodi, et al., "Advances in the Biosciences", vol. 75, Pergamon Press (1989), pp. 25-28.
Hoztafi et al., Chem. Abstr vol. 114 Entry 62427a (1990).
Hoztafi et al. Chem. Abstr vol. 111 entry 23761y (1988).
Hoztafi et al. Chem. Abstr. vol. 108 entry 187032a abstract Hungary 4 06666 (1987).
Bentley, "The Chemistry of the Morphine Alkaloids", Clarendon Press, Oxford, 1954, pp. 179-182, 259, 262.
Goto, et al., Chemical Abstracts, vol. 52, 5440i-544le (1958).
Sargent, et al., Chemical Abstracts, vol. 53, 14133a-14134c (1959).
Liu, et al., Chemical Abstracts, vol. 100, 121411b (1984).
Kolb, et al., Chemical Abstracts, vol. 101, 152154v (1984).
Szucs, et al., MTA Biol. Oszt. Kozl., vol. 25 p. 655 (1982).
Stein, Pharmazie, vol. 10, pp. 180-186 (1955).
Speyer, et al., Berichte, vol. 57, pp. 1422-1427 (1924).
Galetta, et al., Life Sciences, vol. 31, pp 1389-1392 (1982).
Pasternak, Life Sciences, vol. 31, pp. 1303-1306 (1982).
Weiss, et al., J. Org. Chem., vol. 14, pp. 194-203 (1949).
Hahn, et al., J. Neuroscience, vol. 2, No. 5, pp. 572-576 (1982).
Pasternak, J. Med. Chem., vol. 23, pp. 674-676 (1980).
Kolb, et al., J. Org. Chem., vol. 49, pp. 3824-3828 (1984).
Kolb, et al., Life Sciences, vol. 33, suppl. 1, pp. 419-422 (1983).
Hahn, et al., Life Sciences, vol. 31, pp. 1385-1388 (1982).

Affiliated with

Also associated with

Rating

Morphinane-skeletoned hydrazone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Morphinane-skeletoned hydrazone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Morphinane-skeletoned hydrazone derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2270489