Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-06
2010-02-02
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S045000, C546S044000
Reexamination Certificate
active
07655671
ABSTRACT:
The present invention relates to a class of morphinan compounds and quaternary ammonium salts thereof, substituted in Position 14, which may be used as highly active analgesics or also as opioid antagonists. The present invention also relates to the pharmaceutically acceptable salts and easily produced derivatives thereof, a process for the production thereof and use thereof in the production of pharmaceutical specialities.
REFERENCES:
patent: 4176186 (1979-11-01), Goldberg et al.
patent: 4272540 (1981-06-01), Razdan et al.
patent: 4390699 (1983-06-01), Brossi et al.
patent: 4912114 (1990-03-01), Revesz
patent: 6136817 (2000-10-01), Schmidhammer
patent: 3412727 (1985-10-01), None
patent: 0 030 685 (1981-06-01), None
patent: 0 250 796 (1988-01-01), None
patent: 1300419 (1972-12-01), None
patent: WO2004/005294 (2004-01-01), None
Chen-Yu Cheng, et al., “N-Cubylmethyl Substituted Morphinoids as Novel Narcotic Antagonists”,Bioorganic&Medicinal Chemistry, vol. 4, No. 1, pp. 73-80, 1996.
A. Coop, et al., “Delta Opioid Binding Selectivity of 3-Ether Analogs of Naltrindole”,Bioorganic&Medicinal Chemistry Letters, 9 (1999) 3435-3438.
J. Schütz, et al., “Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 17. Highly δ Opioid Receptor Selective 14-Alkoxy-Substituted Indolo- and Benzofuromorphinans”,J. Med. Chem. 2002, 45, 5378-5383.
H. Schmidhammer, et al., “Synthesis and Biological Evaluation of 14- Alkoxymorphinans. 1. Highly Potent Opioid Agonists in the Series of(-)—14 MethoxyN-methylmorphinan-6-ones”,J. Med. Chem., 1964, 27, 1575-1579.
P. Klein, et al., “O3-(2-Carbomethoxyally1) Ethers of Opioid Ligands Derived from Oxymorphone, Naltrexone, Etorphine, Diprenorphine, Norbinaltorphimine, and Naltrindole. UnexpectedO3-Dealkylation in the Opioid Radioligand Displacement Assay”,J. Med. Chem., 1992, 35, 4589-4594.
P.S. Portoghese, et al., “Synthesis of Naltrexone-Dervied δ-Opioid Antagonists. Role of Conformation of the δ Address Moiety”,J. Med. Chem., 1994, 37, 579-585.
C. W. Funke, et al., “A1H and13C Nuclear Magnetic Resonance Study of Three Quaternary Salts of Naloxone and Qxymorphone”,J. Chem. Soc. Perkin Trans. II, 1986, pp. 735-738.
“Synthesis of 14-alkoxymorphinan-6-ones (starting from Naltrexon) as Potential δ-opioid Receptor Antagonists”, Thesis for the Degree of Ph.D. in Natural Sciences of the Leopold-Franzens University of Innsbruck, Submitted by Mag. Pharm. Roland Krassnig, Innsbruck 1994.
Greiner Elisabeth
Sailer Bettina
Schmidhammer Helmut
Schüllner Falko
Schutz Johannes
Alcasynn Pharmaceuticals GmbH
Aulakh Charanjit S
Cohen Pontani Lieberman & Pavane LLP
LandOfFree
Morphinan derivatives, the quaternary ammonium salts thereof... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Morphinan derivatives, the quaternary ammonium salts thereof..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Morphinan derivatives, the quaternary ammonium salts thereof... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4227793