More complex type retroviruses having mixed type LTR, and uses t

Details More complex type retroviruses having mixed type LTR, and uses t More complex type retroviruses having mixed type LTR, and uses t

1994-06-22

1996-09-10

Budens, Robert D.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4353201, 536 2372, 536 241, 4241991, C12N 700, C12N 701, C12N 1500, C12N 1509

Patent

active

055545246

ABSTRACT:
Chimeric retroviral vectors were constructed containing the long terminal repeats (LTRs) from a simple retrovirus (e.g. spleen necrosis virus (SNV); murine leukemia virus (MLV)) devoid of the integration site (att) and more complex retroviral (e.g. bovine leukemia virus (BLV); human immunodeficiency virus (HIV)) cis-acting regulatory sequences (e.g. att; primer binding site (PBS); encapsidation site (E), and polypurine tract (ppt)) and coding regions. Cells transfected with these constructs produce replication competent retrovirus particles. These retroviral particles provide a source of viral antigens that can be employed in both diagnostic assays and as immunogens for the production of high-titer specific antisera.

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