Montoxic extract of Larrea tridentata and method of making the s

Details Montoxic extract of Larrea tridentata and method of making the s Montoxic extract of Larrea tridentata and method of making the s

1998-09-11

1999-08-31

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A01N 6500

Patent

active

059451068

ABSTRACT:
A nontoxic, therapeutic agent having pharmacological activity comprising concentrated extract of Larrea tridentate plant material and ascorbic acid is made by a process in which the plant material is extracted using an organic solvent, and is then saturated with ascorbic acid to reduce the toxic NDGA quinone, which naturally occurs in the plant material, to NDGA itself. Additional amounts of ascorbic acid are added to the extract to inhibit the natural oxidation of the NDGA into the toxic NDGA quinone in vivo, or during processing or storage. The resulting extract is useful in the treatment of viral diseases caused by viruses from the Herpesviridae family or viruses which require the Sp1 class of proteins to initiate viral replications. The resulting compound can also be used as an anti-inflammatory when the inflammatory diseases are mediated by the effects of leukotrienes. The listed reducing agents can also be used to stabilize NDGA as a therapeutic agent or a food additive.

REFERENCES:
patent: 2382475 (1945-08-01), Gisvold
patent: 4765927 (1988-08-01), Nomura et al.
patent: 4774229 (1988-09-01), Jordan
patent: 4880637 (1989-11-01), Jordan
patent: 5276060 (1994-01-01), Neiss et al.
Timmermann "Practical uses of Larrea in Creosote Bush," in "Biology and Chemistry of Larrea in the New World Deserts," Mabry et al. eds. (1977) (Dowden, Hutchinson and Ross: Pennsylvania) pp. 252-276.
Gnabre et al. "Isolation of anti-HIV lignans from Larrea tridentata," Tetrahedron (1995) 51(4(:12203-12210.

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