Data processing: structural design – modeling – simulation – and em – Simulating nonelectrical device or system – Biological or biochemical
Reexamination Certificate
2007-03-16
2010-10-19
Zeman, Mary K (Department: 1631)
Data processing: structural design, modeling, simulation, and em
Simulating nonelectrical device or system
Biological or biochemical
C707S793000, C702S019000, C356S244000, C422S067000, C436S172000
Reexamination Certificate
active
07818154
ABSTRACT:
The subject matter described herein includes a method for modeling fluorescence in turbid media and methods and systems for using the model to determine intrinsic fluorescence of turbid media. According to one aspect, a method for modeling fluorescence of a turbid medium and for using the model to determine intrinsic fluorescence in the turbid medium is provided. The method includes illuminating a turbid medium of interest with an electromagnetic radiation source using a probe of a particular geometry and detecting measured fluorescence for the turbid medium using the probe. At least one set of Monte Carlo simulations is run to determine an escape energy probability map and an absorbed energy density map for the turbid medium. An indication of the intrinsic fluorescence of the turbid medium is determined using the escape probability density map and the absorbed energy density map in a manner that accounts for the geometry of the probe.
REFERENCES:
patent: 4580895 (1986-04-01), Patel
patent: 5203328 (1993-04-01), Samuels et al.
patent: 5439578 (1995-08-01), Dovichi et al.
patent: 5452723 (1995-09-01), Wu et al.
patent: 5529391 (1996-06-01), Kindman et al.
patent: 5582168 (1996-12-01), Samuels et al.
patent: 5813403 (1998-09-01), Soller et al.
patent: 5924981 (1999-07-01), Rothfritz et al.
patent: 5976892 (1999-11-01), Bisconte
patent: 6055451 (2000-04-01), Bambot et al.
patent: 6219566 (2001-04-01), Weersink et al.
patent: 6411373 (2002-06-01), Garside et al.
patent: 6564088 (2003-05-01), Soller et al.
patent: 6577391 (2003-06-01), Faupel et al.
patent: 6590651 (2003-07-01), Bambot et al.
patent: 6678541 (2004-01-01), Durkin et al.
patent: 6813515 (2004-11-01), Hashimshony
patent: 6850656 (2005-02-01), Bevilacqua et al.
patent: 6870620 (2005-03-01), Faupel et al.
patent: 6912412 (2005-06-01), Georgakoudi et al.
patent: 6965345 (2005-11-01), Bae et al.
patent: 6975899 (2005-12-01), Faupel et al.
patent: 7006220 (2006-02-01), Bambot et al.
patent: 7030988 (2006-04-01), Kubo et al.
patent: 7062333 (2006-06-01), Mizutani
patent: 7064837 (2006-06-01), Mori et al.
patent: 7082325 (2006-07-01), Hashimshony et al.
patent: 7113424 (2006-09-01), Happ et al.
patent: 7129454 (2006-10-01), O'Connell et al.
patent: 7145645 (2006-12-01), Blumenfeld et al.
patent: 7184824 (2007-02-01), Hashimshony
patent: 7236815 (2007-06-01), Richards-Kortum et al.
patent: 7411680 (2008-08-01), Chang et al.
patent: 7570988 (2009-08-01), Ramanujam et al.
patent: 2002/0055671 (2002-05-01), Wu et al.
patent: 2002/0114734 (2002-08-01), Pantoliano et al.
patent: 2006/0247532 (2006-11-01), Ramanujam et al.
patent: 2007/0019199 (2007-01-01), Palmer et al.
patent: 2008/0056957 (2008-03-01), Hayman
patent: 2008/0270091 (2008-10-01), Ramanujam et al.
patent: 2009/0015826 (2009-01-01), Ramanujam et al.
patent: WO 02/40971 (2002-05-01), None
patent: WO 2007/014188 (2007-02-01), None
patent: WO 2007/109126 (2007-09-01), None
patent: WO 2008/103486 (2008-08-01), None
patent: WO 2009/043045 (2009-04-01), None
patent: WO 2009/043050 (2009-04-01), None
patent: WO 2009/132360 (2009-10-01), None
Palmer et al., “Monte Carlo-Based Inverse odel for Calculating Tissue Optical Properties. Part I: Theory and Valdiation on Synthetic Phantoms,” Applied Optics, vol. 45, No. 5, pp. 1062-1071 (Feb. 10, 2006).
Palmer et al., “Monte Carlo-Based Inverse Model for Calculating Tissue Optical Properties. Part II: Application to Breast Cancer Diagnosis,” Applied Optices, vol. 45, No. 5, pp. 1072-1078 (Feb. 10, 2006).
Chang et al., “Analytical Model to Describe Fluorescence Spectra of Normal and Preneoplastic Epithelial Tissue: Comparison with Monte Carlo Simulations and Clinical Measurements,” Journal of Biomedical Optics, vol. 9, No. 3, pp. 511-522 (May/Jun. 2004).
Biswal et al., “Recovery of Turbidity Free Fluorescence from Measured Fluorescence: An Experimental Approach,” Optics Express, vol. 11, No. 24, pp. 3320-3331 (Dec. 1, 2003).
Diamond et al., “Quantification of Fluorophore Concentration in Tissue-Simulating Media by Fluorescence Measurements with a Single Optical Fiber,” Applied Optics, vol. 42, No. 13, pp. 2436-244 (May 1, 2003).
Swartling et al., “Accelerated Monte Carlo Models to Simulate Fluorescence Spectra from Layered Tissues,” Journal of Optical Society of America, vol. 20, No. 4, pp. 714-727 (Apr. 2003).
Diamond et al., “Measurement of Fluorophore Concentrations and Fluorescence Quantum Yield in Tissue-Simulating Phantoms Using Three Diffusion Models of Steady-State Spatially Resolved Fluorescence,” Physics in Medicine and Biology, vol. 48, pp. 4135-4149 (2003).
Ma et al., “Determination of Complex Refractive Index of Polystyrene Microspheres from 370 to 1610 nm,” Physics in Medicine and Biology, vol. 48, pp. 4165-4172 (2003).
Weersink et al., “Noninvasive Measurement of Fluorophore Concentration in Turbid Media with a Simple Fluorescence/Reflectance Ratio Technique,” Applied Optics, vol. 40, No. 34, pp. 6389-6395 (Dec. 1, 2001).
Müller et al., “Intrinsic Fluorescence Spectroscopy in Turbid Media: Disentangling Effects of Scattering and Absorption,” Applied Optics, vol. 40, No. 25, pp. 4633-4646 (Sep. 1, 2001).
Ramanujam, “Fluorescence Spectroscopy in Vivo,” Encyclopedia of Analytical Chemistry, pp. 20-56 (2000).
Yu et al., “Quasi-Discrete Hankel Transform,” Optical Letters, vol. 23, No. 6, pp. 409-411 (Mar. 15, 1998).
Chance et al., “Biochemical Distinctions Between Normal and Cancerous Human Breast Tissues Obtained from Fluorescence Spectroscopy,” Proceedings of Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, Biomedical Optics, vol. 2979, pp. 585-588 (Feb. 9-12, 1997).
Zhang et al., “Innate Cellular Fluorescence Reflects Alterations in Cellular Proliferation,” Lasers in Surgery and Medicine, vol. 20, pp. 319-331 (1997).
Gardner et al., “Fluorescence Spectroscopy of Tissue: Recovery of Intrinsic Fluorescence from Measured Fluorescence,” Applied Optics, vol. 35, No. 10, pp. 1780-1792 (Apr. 1, 1996).
Graaff et al., “Condensed Monte Carlo Simulations for the Description of Light Transport,” Applied Optics, vol. 32, No. 4, pp. 426-434 (Feb. 1, 1993).
Zhu et al., “Diagnosis of Breast Cancer Using Diffuse Reflectance Spectroscopy: Comparison of a Monte Carlo Versus Partial Least Squares Analysis Based Feature Extraction Technique.” Lasers in Surgery and Medicine, vol. 38, pp. 714-724 (2006).
Palmer, “Experimental, Computational, and Analytical Techniques for Diagnosing Breast Cancer Using Optical Spectroscopy,” Dissertation, University of Wisconsin-Madison, pp. 1-188 (2005).
Amelink et al., “Measurement of the Local Optical Properties of Turbid Media by Differential Path-Length Spectroscopy,” Applied Optics, vol. 43, No. 15, pp. 3048-3054 (May 20, 2004).
Breslin et al., “Autofluorescence and Diffuse Reflectance Properties of Malignant and Benign Breast Tissues,” Annals of Surgical Oncology, vol. 11, No. 1, pp. 65-70 (Mar. 31, 2004).
Mourant et al., “Measuring Absorption Coefficients in Small Volumes of Highly Scattering Media: Source-Detector Separations for which Path Lengths do not Depend on Scattering Properties,” Applied Optics, vol. 36, No. 22, pp. 5655-5661.
Interview Summary for U.S. Appl. No. 11/493,020 (Nov. 17, 2009).
Liu et al., “Sequential Estimation of Optical Properties of a Two-layered Epithelial Tissue Model From Depth-Resolved Ultraviolet-visible Diffuse Relectance Spectra,” Applied Optics, vol. 45, No. 19, pp. 4776-4790 (Jul. 1, 2006).
Official Action for U.S. Appl. No. 11/729,967 (May 28, 2009).
PCT International Application Serial No. PCT/US09/41857 for “Systems and Methods for Performing Optical Spectroscopy Using a Self-Calibrating Fiber Optic Probe” (Apr. 27, 2009).
Office Action for U.S. Appl. No. 11/493,020 (Apr. 24, 2009).
PCT Inter
Palmer Gregory M.
Ramanujam Nirmala
Duke University
Jenkins Wilson Taylor & Hunt, P.A.
Zeman Mary K
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