Monotherapy of peptic ulcers and gastritis

Details Monotherapy of peptic ulcers and gastritis Monotherapy of peptic ulcers and gastritis

1997-08-12

1999-05-04

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 82, 544337, A61K 31675, C07F 96561, C07F 96558

Patent

active

059004100

ABSTRACT:
The present invention is directed to compositions, methods and kits for treating areas of H. pylori infection in the GI tract. The active ingredient is an antibiotic-bisphosphonate adduct wherein the antibiotic is selected for its ability to eradicate H. pylori. Other components include a salt of a divalent cation that is insolubilized in vivo at alkaline pH, and optionally a substrate from which the enzyme urease liberates NH.sub.3.

REFERENCES:
patent: 5409903 (1995-04-01), Polak et al.
patent: 5476669 (1995-12-01), Borody
patent: 5498699 (1996-03-01), Djokic et al.
patent: 5674858 (1997-10-01), McColm

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