Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-07-25
1999-03-02
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 91, 4241331, 4241391, 4241451, 435 792, 435 13, 435 696, 435 7021, 43524027, 435972, 435975, 436516, 436518, 436524, 436528, 436530, 436531, 436538, 436548, 5303873, 5303879, 53038825, 5303911, 935 15, 935104, 935107, 935108, G01N 3353, G01N 33543, G01N 33536, C07K 1636
Patent
active
058769471
ABSTRACT:
The invention provides monospecific antibodies that are specifically reactive with fibrinopeptide B (FPB) and with fibrinogen and fragments thereof containing the amino acid sequence defined by SEQ ID NO:1. The invention also provides anti-FPB probes, including monospecific anti-FPB antibodies that have been detectably labeled. In addition, the invention provides methods of using the monospecific antibodies for detection of fibrinopeptide B, as well as reagents and kits for performing the methods. For example, the invention provides a method for detecting fibrinopeptide B with specificity in biological samples such as blood samples, by using the antibody to immunometrically bind to the fibrinopeptide B. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis. The invention further provides continuous cell lines (hybridomas) that produce monospecific anti-FPB antibodies.
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Kudryk Bohdan J.
Redman Colvin M.
Zhang Jian-Zhong
Grun James L.
Housel James C.
The New York Blood Center, Inc.
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