Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-10-06
2000-02-15
Housel, James C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424 9467, 435 792, C07K 1600
Patent
active
060254769
ABSTRACT:
The invention provides monospecific antibodies which are specifically reactive with the .alpha..sub.E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti-.alpha..sub.E probes, including monospecific anti-.alpha..sub.E antibodies which have been detectably labeled. In addition, the invention provides methods of using the monospecific antibodies for detection of the .alpha..sub.E subunit and fragments thereof, as well as reagents and kits for performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-.alpha..sub.E antibodies.
REFERENCES:
patent: 5817768 (1998-10-01), Grieninger et al.
patent: 5830468 (1998-11-01), Bini
Blomback B, "Fibrinogen and fibrin formation and its role in fibrinolysis", in Goldstein J, ed., Biotechnology of Blood, 225-279 (1991).
Bini A, and Kudryk BJ, "Fibrin and its derivatives in the normal and diseased vessel wall", Ann. N.Y. Acad. Sci. 667:112-126 (1992).
Dvorak HF, Nagy JA, Berse B, Brown LF, Yeo K-T, Yeo T-K, Dvorak AM, Van de Water L, Sioussat TM, and Senger DR, "Vascular Permeability factor, fibrin, and the pathogenesis of tumor stroma formation", Ann N.Y. Acad. Sci. 667:101-111 (1992).
Fu Y, Weissbach L, Plant PW, Oddoux C, Cao Y, Liang TH, Roy SN, Redman CM, and Grieninger G, "Carboxy-terminal-extended variant of the human fibrinogen .alpha. subunit: a novel exon conferring marked homology to .beta. and .gamma. subunits", Biochemistry 31:11968-11972 (1992).
Blomback B, Blomback M, Henschen A, Hessel B, Iwanaga S, and Woods KR, "N-terminal disulphide knot of human fibrinogen", Nature 218: 130-134 (1968).
Lottspeich F, and Henschen A, "Amino acid sequence of human fibrin. Preliminary note on the completion of the gamma-chain sequence", Hoppe-Seyler's Z. Physiol. Chem. 358:935-938 (1977).
Henschen A, and Lottspeich F, "Amino Acid sequence of human fibrin, preliminary note on the completion of the beta-chain sequence", Hoppe-Seyler's Z. Physiol. Chem. 358:1643-1646 (1977).
Henschen A, Lottspeich F, and Hessel B, "Amino acid sequence of human fibrin, preliminary note on the completion of the intermediate part of the alpha-chain sequence", Hoppe-Seyler's Z. Physiol. Chem. 360:1951-1956 (1979).
Doolittle RF, Watt KWK, Cottrell BA, Strong DD, and Riley M, "The amino acid sequence of the alpha-chain of human fibrinogen", Nature 280:464-468 (1979).
Kant JA, Fornace Jr AJ, Saxe D, Simon MI, McBride OW, and Crabtree GR, "Evolution and organization of the fibrinogen locus on chromosome 4: Gene duplication accompanied by transposition and inversion", Proc. Natl. Acad. Sci. USA 82:2344-2348 (1985).
Chung DW, Harris JE, and Davie EW, "Nucleotide sequences of the three genes coding for human fibrinogen", Adv. Exp. Med. Biol. 281:39-48 (1991).
Weissbach L, and Grieninger G, "Bipartite mRNA for chicken alpha-fibrinogen potentially encodes an amino acid sequence homologous to beta-and gamma-fibrinogens", Proc. Natl. Acad. Sci. USA 87:5198-5202 (1990).
Fu Y, and Grieninger G, "Fib.sub.420 : A normal human variant of fibrinogen with two extended .alpha. chains", Proc. Natl. Acad. Sci. USA 91:2625-2628 (1994).
Pan Y, and Doolittle RF, "cDNA sequence of a second fibrinogen alpha chain in lamprey: An archetypal version alignable with full-length beta and gamma chains", Proc. Natl. Acad. Sci. USA 89:2066-2070 (1992).
Doolittle RF, Riley M, and Pan Y, "Direct measurement of a second fibrinogen alpha chain in lamprey blood plasma", Thromb. Res. 68:489-493 (1992).
Chung DW, Que BG, Rixon MW, Mace Jr M, and Davie EW, "Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen", Biochemistry 22:3244-3250 (1983).
Chung DW, Chan W-Y, and Davie EW, "Characterization of a complementary deoxyribonucleic acid coding for the gamma chain of human fibrinogen", Biochemistry 22:3250-3256 (1983).
Baker NE, Mlodzik M, and Rubin GM, "Spacing differentiation in the developing Drosophila eye: A fibrinogen-related lateral inhibitor encoded by scabrous", Science 250:1370-1377 (1990).
Koyama T, Hall LR, Haser WG, Tonegawa S, and Saito H, "Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains", Proc. Natl. Acad. Sci. USA 84:1609-1613 (1987).
Morel Y, Briston J, Gitelman SE, and Miller WL, "Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus", Proc. Natl. Acad. Sci. USA 86:6582-6586 (1989).
Nies DE, Hemesath TJ, Kim J-H, Gulcher JR, and Stefansson K, "The complete cDNA sequence of human hexabreachion (tenascin)", J. Biol. Chem. 266:2818-2823 (1991).
Norenberg U, Wille H, Wolff JM, Frank R, and Rathjen FG, "The chicken neural extracellular matrix molecule restrictin: Similarity with EGF-, fibronectin type III-, and fibrinogen-like motifs", Neuron 8:849-863 (1992).
Xu X, and Doolittle RF, "Presence of a vertebrate fibrinogen-like sequence in an echinoderm", Proc. Natl. Acad. Sci. USA 87:2097-2101 (1990).
Chan AM-L, Rubin JS, Bottaro DP, Hirschfield DW, Chedid M, and Aaronson SA, "Identification of a competitive HGF antagonist encoded by an alternative transcript", Science 254:1382-1385 (1991).
Descombes P, and Schibler U, "A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA", Cell 67:569-579 (1991).
Early P, Rogers J, David M, Calame K, Bond M, Wall R, and Hood L, "Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways", Cell 20:313-319 (1980).
Hynes RO, "Integrins: Versatility, modulation, and signaling in cell adhesion", Cell 69:11-25 (1992).
Kloczewiak M, Timmons S, Lukas TJ, and Hawiger J, "Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain", Biochemistry 23:1767-1774 (1984).
Cheresh DA, Berliner SA, Vincente V, and Ruggeri ZM, "Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells", Cell 58:945-953 (1989).
Loike JD, Sodeik B, Cao L, Leucona S. Weitz JI, Detmers PA, Wright SD, and Silverstein SC, "CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A-alpha chain of fibrinogen", Proc. Natl. Acad. Sci. USA 88:1044-1048 (1991).
Farrell DH, Thiagarajan P, Chung DW, and Davie EW, "Role of fibrinogen alpha and gamma chain sites in platelet aggregation", Proc. Natl. Acad. Sci. USA 89:10729-10732 (1992).
Gonda SR, and Shainoff JR, "Adsorptive endocytosis of fibrin monomer by macrophages: Evidence of a receptor for the amino terminus of the fibrin alpha chain", Proc. Natl. Acad. Sci. USA 79:4565-4569 (1982).
Ribes JA, Ni F, Wagner DD, and Francis CW, "Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain", J. Clin Invest. 84:435-442 (1989).
Ernst E, "Plasma fibrinogen--An independent cardiovascular risk factor", J. Internal Med. 227:365-372 (1990).
Ernst E, and Resch KL, "Fibrinogen as a cardiovascular risk factor: A meta-analysis and review of the literature", Ann Intern. Med. 118:956-963 (1993).
Bini A, Fenoglio JJ, Sorbel J, Owen J, Fejgl M, and Kaplan KL, "Immunochemical characterization of fibrinogen, fibrin I, and fibrin II in human thrombi and atherosclerotic lesions", Blood 69:1038-1045 (1987).
Valenzuela R, Shainoff JR, DiBello PM, Urbanic DA, Anderson JM, Matsueda GR, and Kudryk BJ, "Immunoelectrophoretic and immunohistochemical characterizations of fibrinogen derivatives in atherosclerotic aortic intimas and vascular prosthesis pseudo-intimas", Am. J. Pathol. 141:861-880 (1992).
Felding-Habermann B, Ruggeri ZM, and Cheresh DA, "Distinct biological consequences of integrin alpha-v-beta-3-mediated melanoma
Ahadi Mohamad Zaher
Cao Yan
Fu Yiping
Grieninger Gerd
Kudryk Bohdan J.
Housel James C.
New York Blood Center Inc.
Portner Ginny Allen
LandOfFree
Monospecific antibodies against a subunit of fibrinogen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monospecific antibodies against a subunit of fibrinogen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monospecific antibodies against a subunit of fibrinogen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1906993