Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-07-01
2000-02-15
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 9462, 5303881, C07K 1600
Patent
active
060251484
ABSTRACT:
The invention provides monospecific antibodies which are specifically reactive with the .alpha.hd E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti-.alpha..sub.E probes, including monospecific anti-.alpha..sub.E antibodies which have been detectably labeled. In addition, the invention provides methods of using the monospecific antibodies for detection of the .alpha..sub.E subunit and fragments thereof, as well as reagents and kits for performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-.alpha..sub.E antibodies.
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Ahadi Mohamad Zaher
Cao Yan
Fu Yiping
Grieninger Gerd
Kudryk Bohdan J.
Housel James C.
New York Blood Center Inc.
Portner Ginny Allen
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