Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1998-10-06
Housel, James C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
438 79, 438 13, 4381722, 53038825, 5303893, 5303913, 5303911, C07K 1600, C07K 1700, C12P 2108
Patent
active
058177680
ABSTRACT:
The invention provides nonspecific antibodies which are specifically reactive with the .alpha..sub.E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti-.alpha..sub.E probes, including nonspecific anti-.alpha..sub.E antibodies which have been detectably labeled. In addition, the invention provides methods of using the nonspecific antibodies for detection of the .alpha..sub.E subunit and fragments thereof, as well as reagents and kits for performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti-.alpha..sub.E antibodies.
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Ern
Ahadi Mohamad Zaher
Cao Yan
Fu Yiping
Grieninger Gerd
Kudryk Bohdan J.
Housel James C.
Portner Ginny Allen
The New York Blood Center, Inc.
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