Monosaccharide analog-based glycosidase inhibitors

Details Monosaccharide analog-based glycosidase inhibitors Monosaccharide analog-based glycosidase inhibitors

1993-04-29

1995-07-18

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546243, 546249, 546257, 546281, 548541, 548556, 536187, C07D21172, C07D20722

Patent

active

054342660

ABSTRACT:
Broad spectrum glycosidase inhibitors are produced from monosaccharide lactams by conversion to amidines, amidrazones, or amidoximes. The inhibitors have the general formula: ##STR1## wherein the N and C are joined as part of a monosaccharide azaanalog ring and wherein --NRQ, together with the nitrogen and carbon atoms, form a chemical group selected from amidines, amidrazones, and amidoximes.

REFERENCES:
patent: 5231185 (1993-07-01), Ganem et al.
Tong et al, J. Am. Chem. Soc., 1990, 6137-6139.
Bernofas et al, Tetrahedron letters, vol. 131, 1990, 3393-3396.

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