Monoradioiodinated phenolic esters, acids and amines

Details Monoradioiodinated phenolic esters, acids and amines Monoradioiodinated phenolic esters, acids and amines

1976-09-29

1978-10-17

Tovar, Jose

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

560 29, 560 39, 560 75, 2605708R, 562438, 562437, 562445, 562446, 562444, 562465, C07D20740

Patent

active

041208676

ABSTRACT:
Monoradioiodinated derivatives of compounds employed in a radioassay prepared from precursors which are either active esters, amino acids, or amines, including a phenolic or imidazole substituent group in which one of the possible two sites on the group for radioiodination is substituted to permit production of a monoradioiodinated derivative. A preferred precursor is an active ester of 3-fluoro-5-radioidotyrosine which can be coupled to a compound including an amino group to produce a monoradioiodinated derivative of the compound.

REFERENCES:
patent: 3989812 (1976-11-01), Barrett et al.
A. E. Bolton et al. Biochem. J. (1973), 133, 529-539.

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