Monoradioiodinated imidazole derivatives

Details Monoradioiodinated imidazole derivatives Monoradioiodinated imidazole derivatives

1979-05-24

1982-01-12

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548337, 548339, C07D40312, C07D23364, C07D23395

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active

043106757

ABSTRACT:
Monoradioiodinated derivatives of compounds employed in a radioassay prepared from precursors which are either active esters, amino acids, or amines, including a phenolic of imidazole substituent group in which one of the possible two sites on the group for radioiodination is substituted to permit production of a monoradioiodinated derivative. A preferred precursor is an active ester of 3-fluoro-5-radioiodotyrosine which can be coupled to a compound including an amino group to produce a monoradioiodinated derivative of the compound.

REFERENCES:
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Chemical Abstracts, 78:55813h, (1973), [Savoie, J. et al., J. Clin. Invest., 1973, 52(1), 106-115].
Chemical Abstracts, 64:10346g, (1966), [Covelli, I. et al., Biochemistry, 5(3), 860-871, (1966)].
Chemical Abstracts, 88:18611b, (1978), [Read, G. et al., Ann. Clin. Biochem., 1977, 14(6), 343-349].
Chemical Abstracts, 80:68012n, (1974), [Cameron, E. et al., Biochem. Soc. Trans., 1973, 1(5), 1115-1117].
Anderson, G. et al., J. Am. Chem. Soc., 86, 1839-1842, (1964).
Brunings, K., J. Am. Chem. Soc., 69, 205-208, (1947).
Kapoor, A., J. Pharm. Sci. 59(1), 1-27 (1970).

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