Monoradioiodinated derivatives and precursors for production the

Details Monoradioiodinated derivatives and precursors for production the Monoradioiodinated derivatives and precursors for production the

1978-03-10

1980-05-13

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 252408, 260112B, 424 12, G01N 3316, A61K 4300

Patent

active

042028744

ABSTRACT:
Monoradioiodinated derivatives of compounds employed in a radioassay prepared from precursors which are either active esters, amino acids, or amines, including a phenolic or imidazole substituent group in which one of the possible two sites on the group for radioiodination is substituted to permit production of a monoradioiodinated derivative. A preferred precursor is an active ester of 3-fluoro-5-radioiodotyrosine which can be coupled to a compound including an amino group to produce a monoradioiodinated derivative of the compound.

REFERENCES:
patent: 3925355 (1975-12-01), Piasio et al.
patent: 3957963 (1976-05-01), Salmon et al.
patent: 3989812 (1976-11-01), Barrett et al.
patent: 4120867 (1978-10-01), Akerkar et al.
Bolton et al., Biochem. J. (1973) 133, 529-539.

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