Monopolar and bipolar current application for transdermal...

Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...

Reexamination Certificate

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Reexamination Certificate

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07062317

ABSTRACT:
A device for facilitating transdermal passage of a substance through skin on the body of a subject is provided. The device preferably includes afcn electrode and a control unit. In a preferred embodiment, the control unit is adapted to drive the electrode to apply to the skin a current capable of ablating stratum corneum epidermidis of the skin, so as to facilitate transdermal passage of the substance. The control unit detects generation of at least one spark responsive to application of the current, and modifies a parameter of the current responsive to detecting the generation of the at least one spark.

REFERENCES:
patent: 4141359 (1979-02-01), Jacobsen et al.
patent: 6611706 (2003-08-01), Avrahami et al.
patent: 2002/0010414 (2002-01-01), Coston
patent: WO 01/13989 (2001-03-01), None
U.S. Appl. No. 09/644,093, filed Aug. 23, 200, entitled: “Tissue Electroperforation for enhanced Drug delivery”.
U.S. Appl. No. 60/150,636, filed Aug. 25, 1999, entitled: “Tissue Electroperforation for enhanced Drug delivery and Diagnostic Sampling”.

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