Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1980-01-30
1981-05-19
Sutto, Anton H.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
260951, 260961, 424222, A61K 3166, C07F 938, C07F 940
Patent
active
042685079
ABSTRACT:
This invention relates to new monophosphonate compounds of formula X--C.sub.6 H.sub.4 --(O).sub.m --(CH.sub.2).sub.n --R where R is --PO.sub.3 Me.sub.2, --PO.sub.3 Et.sub.2, --PO.sub.3 H.sub.2 or --PO.sub.3 Na.sub.2, X is a halogen, preferably chlorine, in position o, m or p, preferably in position p; m is 0 or 1; and n is 0, 1, 2, 3, 4, 5 or 6, which possess remarkable activity as hypoglycemic and/or antiatherogenic agents, and are usable in pharmaceutical compositions to alter lipoprotein profiles in favor of high density lipoproteins and to clear cholesterol from various tissues.
REFERENCES:
patent: 3524846 (1970-08-01), Moffatt et al.
patent: 4182759 (1980-01-01), Diana
Kosolapoff, et al., "Organic Phosphorus Compounds", vol. 7, (1976), pp. 158, 180, & 223.
Sutto Anton H.
Symphar S.A.
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